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PPQ-102

Product Name
PPQ-102
CAS No.
931706-15-9
Chemical Name
PPQ-102
Synonyms
PPQ-102;CS-1365;CFTR Inhibitor;PPQ 102, >=98%;PPQ-102, CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
CBNumber
CB82628279
Molecular Formula
C26H22N4O3
Formula Weight
438.48
MOL File
931706-15-9.mol
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PPQ-102 Property

Melting point:
>300℃ (ethanol )
Boiling point:
648.7±65.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
-20C
solubility 
DMF: 0.2 mg/ml
form 
White crystalline solid
pka
1.00±0.40(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219677
Product name
CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
Packaging
10mg
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
16275
Product name
PPQ-102
Purity
≥95%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
16275
Product name
PPQ-102
Purity
≥95%
Packaging
10mg
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
16275
Product name
PPQ-102
Purity
≥95%
Packaging
50mg
Price
$710
Updated
2024/03/01
Tocris
Product number
4303
Product name
PPQ102
Purity
≥98%(HPLC)
Packaging
50
Price
$730
Updated
2021/12/16
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PPQ-102 Chemical Properties,Usage,Production

General Description

A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.

storage

Store at -20°C

PPQ-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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PPQ-102 Suppliers

China 59 India 1 United Kingdom 1 United States 16 Global 77
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5729
Advantage
77

931706-15-9, PPQ-102Related Search:

PQR-309(PI3K-IN-2) PP2 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea PQR620 PQR530

  • CS-1365
  • CFTR Inhibitor
  • CFTR INHIBITOR; PPQ102; PPQ 102
  • CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
  • PPQ-102
  • 7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
  • PPQ-102, CFTR Inhibitor
  • 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
  • 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin
  • 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102
  • PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
  • PPQ 102, >=98%
  • Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-
  • 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
  • polycystic kidney disease,E13.5 embryonic kidneys,inhibit,Inhibitor,PPQ-102,CFTR,Cystic fibrosis transmembrane conductance regulator
  • 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
  • 931706-15-9
  • Inhibitors