XL-647

ChemicalBook > CAS DataBase List > XL-647

Product Name: XL-647
CAS No.: 781613-23-8
Chemical Name: XL-647
Synonyms: KD-019;XL-647;Tesevatinib;XL647 /EXEL-7647;Tesevatinib(XL647);EXEL-7647;XL-647;XL 647;Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine;N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine;N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine;4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-
CBNumber: CB82628532
Molecular Formula: C24H25Cl2FN4O2
Formula Weight: 491.3853032
MOL File: 781613-23-8.mol

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XL-647 Property

Boiling point:: 567.9±50.0 °C(Predicted)
Density: 1.356
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form: A solid
pka: 10.16±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27049
Product name: XL647
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 27049
Product name: XL647
Packaging: 10mg
Price: $672
Updated: 2024/03/01

Cayman Chemical

Product number: 27049
Product name: XL647
Packaging: 5mg
Price: $360
Updated: 2024/03/01

ChemScene

Product number: CS-3666
Product name: Tesevatinib
Purity: 99.21%
Packaging: 5mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-3666
Product name: Tesevatinib
Purity: 99.21%
Packaging: 10mg
Price: $648
Updated: 2021/12/16

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XL-647 Chemical Properties,Usage,Production

Uses

XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.

Definition

ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.

XL-647 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from XL-647 manufacturers

Career Henan Chemical Co

Product: XL-647 781613-23-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

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Tesevatinib

Tesevatinib(XL647)

XL-647

N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine

N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine

EXEL-7647;XL-647;XL 647

KD-019

Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine

XL647,Tesevatinib,EXEL 7647,KD019,HER1,Ephrin Receptor,Inhibitor,VEGFR,KD 019,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,EGFR,ErbB-1,XL 647,EXEL7647,inhibit

XL647 /EXEL-7647

4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-

N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine

781613-23-8

C24H25Cl2FN4O2