ChemicalBook > CAS DataBase List > 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

Product Name: 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
CAS No.: 22246-12-4
Chemical Name: 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
Synonyms: 6-METHOXY-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE;105298;in-1(2H)-one;6-Methoxy-3,4-dihydroisoquinoL;6-METHOXY-3,4-1(1H)-ISOQUINOLINONE;6-methoxy-3,4-dihydroisoquinolin-1-ol;3,4-Dihydro-6-methoxy-1(2H)-isoquinolinone;6-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE;6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;1(2H)-Isoquinolinone, 3,4-dihydro-6-methoxy-
CBNumber: CB8263452
Molecular Formula: C10H11NO2
Formula Weight: 177.2
MOL File: 22246-12-4.mol

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6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Property

Melting point:: 136-138℃
Boiling point:: 439.8±45.0 °C(Predicted)
Density: 1.159
storage temp.: Sealed in dry,Room Temperature
pka: 14.77±0.20(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C10H11NO2/c1-13-8-2-3-9-7(6-8)4-5-11-10(9)12/h2-3,6H,4-5H2,1H3,(H,11,12)
InChIKey: WLQWIZAWNPYMBR-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=C(OC)C=C2)CCN1

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M265453
Product name: 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: P000387188
Product name: 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
Purity: 97%
Packaging: 1g
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 072195
Product name: 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
Purity: 95+%
Packaging: 1g
Price: $79
Updated: 2021/12/16

ChemScene

Product number: CS-0018999
Product name: 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
Packaging: 1g
Price: $101
Updated: 2021/12/16

Ark Pharm

Product number: P000387188
Product name: 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
Purity: 97%
Packaging: 5g
Price: $212
Updated: 2021/12/16

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6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Usage,Production

Synthesis

110192-21-7

22246-12-4

General procedure for the synthesis of 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolinone from the compound (CAS:110192-21-7): the feedstock compound (35.0 g, 167.26 mmol) was slowly added to preheated polyphosphoric acid (184 mL, 183.99 mmol) at 120 °C, keeping the temperature at 120 °C. The reaction mixture was stirred at room temperature for 6 h. Subsequently, the reaction was quenched with ice water, alkalized with K2CO3 to pH neutral and extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous Na2SO4, filtered and the solvent concentrated. The crude product was purified by silica gel column chromatography using ethyl acetate (EtOAc)/hexane (1:1) as eluent to afford the target product 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolone (38.5 g, 218 mmol, 76% yield) as a white solid.1H NMR (500 MHz, CDCl3) δ 8.01 (d, J = 8.7 Hz, 1H), 6.90 (d, J = 8.7 Hz, 1H), 6.86 (dd, J = 8.7, 2.4 Hz, 1H), 6.71 (d, J = 2.4 Hz, 1H), 3.85 (s, 3H), 3.56 (td, J = 6.6, 2.8 Hz, 2H), 2.96 (t, J = 6.6 Hz, 2H); EI/ MS m/z 177.1 [M+].

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 207 - 219
[2] Patent: US2017/145007, 2017, A1. Location in patent: Paragraph 0322-0325
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 789 - 801
[4] Patent: WO2012/97682, 2012, A1. Location in patent: Page/Page column 134
[5] Patent: WO2012/97684, 2012, A1. Location in patent: Page/Page column 108

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE manufacturers

Career Henan Chemical Co

Product: 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 22246-12-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

22246-12-4, 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONERelated Search:

6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid 6-METHOXY-1,2,3,4-TETRAHYDROQUINOLINE 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE narciclasine 3,4-Dihydro-2H-isoquinolin-1-one 7,8-DIHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5(6H)-ONE 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 7-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6-METHOXY-1,4-DIHYDRO-2H-ISOQUINOLIN-3-ONE AKOS 237-34 AKOS 233-98 AKOS 213-63 8-AMINO-7,8-DIHYDRO-6H-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5-ONE HCL 2,2,2-TRIFLUORO-N-(5-OXO-5,6,7,8-TETRAHYDRO[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-8-YL)ACETAMIDE N-(6,7-DIMETHOXY-1-OXO-1,2,3,4-TETRAHYDRO-4-ISOQUINOLINYL)-2,2,2-TRIFLUOROACETAMIDE 6-METHOXY-2-PHENYL-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE

6-METHOXY-3,4-1(1H)-ISOQUINOLINONE

1(2H)-Isoquinolinone, 3,4-dihydro-6-methoxy-

6-(Methyloxy)-3,4-dihydro-1(2H)-isoquinolinone

6-Methoxy-1,2,3,4-tetrahydroisoquinolin-1-one

6-METHOXY-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-Methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline

6-methoxy-3,4-dihydroisoquinolin-1-ol

3,4-Dihydro-6-methoxy-1(2H)-isoquinolinone

105298

6-Methoxy-3,4-dihydroisoquinoL

in-1(2H)-one

22246-12-4

Quinoline series