6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
- Product Name
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
- CAS No.
- 42923-77-3
- Chemical Name
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
- Synonyms
- m90104;6-Methoxy-1;AKOS BC-2988;Longimammatine;CHEMBRDG-BB 4101917;4-tetrahydroisoquinolin;6-Methoxy-1,2,3,4-tetrahydroisoquinolin;6-Methoxy-1,2,3,4-tetrahydroisochinolin;1,2,3,4-tetrahydro-6-methoxy-isoquinolin;1,2,3,4-Tetrahydro-6-methoxyisoquinoline
- CBNumber
- CB8386342
- Molecular Formula
- C10H13NO
- Formula Weight
- 163.22
- MOL File
- 42923-77-3.mol
6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Property
- Boiling point:
- 144°C/9mmHg(lit.)
- Density
- 1.044±0.06 g/cm3(Predicted)
- refractive index
- 1.5660 to 1.5700
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- Pale Yellow to Yellow Semi-Solid
- pka
- 10.02±0.20(Predicted)
- color
- Colorless to Light orange to Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2781
- Product name
- 6-Methoxy-1,2,3,4-tetrahydroisoquinoline
- Purity
- >96.0%(GC)(T)
- Packaging
- 1g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- M2781
- Product name
- 6-Methoxy-1,2,3,4-tetrahydroisoquinoline
- Purity
- >96.0%(GC)(T)
- Packaging
- 5g
- Price
- $412
- Updated
- 2021/12/16
- Product number
- M268675
- Product name
- 6-Methoxy-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J96775
- Product name
- 6-Methoxy-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 053802
- Product name
- 6-Methoxy-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Chemical Properties,Usage,Production
Uses
6-Methoxy-1,2,3,4-tetrahydroisoquinoline is used in the synthesis of novel spirobicyclic Artemisinin (A777500) analogues for anti-tumor activity.
Synthesis
22246-12-4
42923-77-3
6.1.18 Synthesis of 6-methoxy-1,2,3,4-tetrahydroisoquinoline (35): to an anhydrous tetrahydrofuran (THF, 20 mL) solution of 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolone (34, 1.4 g, 7.9 mmol) was added slowly under nitrogen protection lithium aluminum hydride (LiAlH4, 601 mg, 15.8 mmol). The reaction mixture was stirred at 60 °C overnight. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by sequential addition of water (0.6 mL) and 15% sodium hydroxide (NaOH) solution (0.6 mL), and stirring was continued for 30 minutes. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=20:1) to afford the target product 35 (1.06 g, 77% yield) as a yellow oil.1H NMR (400 MHz, CDCl3): δ 6.94 (d, J=8.0 Hz, 1H), 6.71 (d, J=8.0 Hz, 1H), 6.63 (s 1H), 4.00 (s, 2H), 3.78 (s, 3H), 3.16 (t, J=5.6Hz, 2H), 2.83 (t, J=5.2Hz, 2H).
References
[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 12, p. 2208 - 2216
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993, vol. 32, # 12, p. 1209 - 1213
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 207 - 219
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 789 - 801
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6855 - 6868
6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-34975603-808 18721111801
- Fax
- +86-21-34975602-805
- sales@bocpharma.com
- Country
- China
- ProdList
- 1009
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 519-519-88783621 13906127738
- Fax
- +86-519-88495082
- xjq@xialichem.com
- Country
- China
- ProdList
- 170
- Advantage
- 70
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
View Lastest Price from 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE manufacturers
- Product
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 42923-77-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-03-05
- Product
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 42923-77-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22