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FIIN-1

Product Name
FIIN-1
CAS No.
1256152-35-8
Chemical Name
FIIN-1
Synonyms
FIIN-1;FIIN 1,FIIN1;FIIN 1 hydrochloride;N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide;2-Propenamide, N-[3-[[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
CBNumber
CB82653864
Molecular Formula
C32H39Cl2N7O4
Formula Weight
656.6
MOL File
1256152-35-8.mol
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FIIN-1 Property

Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
13.54±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4002
Product name
FIIN1hydrochloride
Purity
≥96%(HPLC)
Packaging
10
Price
$253
Updated
2021/12/16
Tocris
Product number
4002
Product name
FIIN1hydrochloride
Purity
≥96%(HPLC)
Packaging
50
Price
$1034
Updated
2021/12/16
TRC
Product number
F336500
Product name
FIIN-1
Packaging
10mg
Price
$185
Updated
2021/12/16
Usbiological
Product number
255301
Product name
FIIN 1 hydrochloride
Packaging
10mg
Price
$516
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0008601
Product name
FIIN-1
Purity
95.00%
Packaging
5MG
Price
$450.15
Updated
2021/12/16
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FIIN-1 Chemical Properties,Usage,Production

Uses

FIIN-1 is a fibroblast growth factor receptor (FGFR) Irreversible Inhibitor 1.The fibroblast growth factor receptor tyrosine kinases are promising therapeutic targets in a number of cancers and FIIN-1 is a useful probe of FGFR-dependent cellular phenomena and may assist in the development of therapeutically relevant irreversible inhibitors, particularly for wild-type and drug-resistant forms of FGFR kinases.

Uses

FIIN-1 is a fibroblast growth factor receptor (FGFR) Irreversible Inhibitor 1 (1).The fibroblast growth factor receptor tyrosine kinases are promising therapeutic targets in a number of cancers and FIIN-1 is a useful probe of FGFR-dependent cellular phenomena and may assist in the development of therapeutically relevant irreversible inhibitors, particularly for wild-type and drug-resistant forms of FGFR kinases.

IC 50

FGFR1: 2.8 nM (Kd); FGFR2: 6.9 nM (Kd); FGFR3: 5.4 nM (Kd); FGFR4: 120 nM (Kd); FGFR1: 9.2 nM (IC50); FGFR2: 6.2 nM (IC50); FGFR3: 11.9 nM (IC50); FGFR4: 189 nM (IC50)

storage

Store at -20°C

FIIN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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FIIN-1 Suppliers

Canada 1 China 23 India 1 United Kingdom 1 United States 3 Global 29
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71

1256152-35-8, FIIN-1Related Search:


  • FIIN-1
  • N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
  • FIIN 1 hydrochloride
  • FIIN 1,FIIN1
  • 2-Propenamide, N-[3-[[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
  • 1256152-35-8
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors