Ethyl 2-chloro-5-Methylnicotinate

Product Name: Ethyl 2-chloro-5-Methylnicotinate
CAS No.: 894074-85-2
Chemical Name: Ethyl 2-chloro-5-Methylnicotinate
Synonyms: Ethyl 2-chloro-5-Methylnicotinate;ethyl 2-chloro-5-methyl-pyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-chloro-5-methyl-, ethyl ester
CBNumber: CB82665841
Molecular Formula: C9H10ClNO2
Formula Weight: 199.63
MOL File: 894074-85-2.mol

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Ethyl 2-chloro-5-Methylnicotinate Property

Boiling point:: 285.7±35.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.92±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0368760
Product name: ETHYL-2-CHLORO-5-METHYLNICOTINATE
Purity: 95.00%
Packaging: 5MG
Price: $505.35
Updated: 2021/12/16

AK Scientific

Product number: 4795AC
Product name: Ethyl2-chloro-5-methylnicotinate
Packaging: 25g
Price: $3594
Updated: 2021/12/16

Chemenu

Product number: CM126212
Product name: ethyl2-chloro-5-methylnicotinate
Purity: 98%
Packaging: 5g
Price: $737
Updated: 2021/12/16

Crysdot

Product number: CD11026563
Product name: Ethyl2-chloro-5-methylnicotinate
Purity: 98%
Packaging: 5g
Price: $780
Updated: 2021/12/16

Ambeed

Product number: A238502
Product name: Ethyl2-chloro-5-methylnicotinate
Purity: 98%
Packaging: 5g
Price: $940
Updated: 2021/12/16

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Ethyl 2-chloro-5-Methylnicotinate Chemical Properties,Usage,Production

Synthesis

64-17-5

66909-30-6

894074-85-2

General procedure for the synthesis of ethyl 2-chloro-5-methylnicotinate from ethanol and 2-chloro-5-methylnicotinic acid: to a solution of 2-chloro-5-methylnicotinic acid (3.90 g, 22.7 mmol) in dichloromethane (DCM, 100 mL) was added oxaloyl chloride (9.95 mL, 114 mmol) followed by 1 drop of N,N-dimethylformamide (DMF). The reaction mixture was stirred at room temperature for 30 min, followed by evaporation of the solvent under vacuum. The resulting residue was dissolved in ethanol (EtOH, 66 mL) and stirring was continued for 2 h, after which the solvent was again evaporated under vacuum. The crude product was purified by fast column chromatography (silica gel SiO2, 120 g, eluent was a gradient solution of 0-50% dichloromethane in isohexane) to afford the target compound ethyl 2-chloro-5-methylnicotinate as a colorless oil (3.71 g, 82% yield).1H NMR (δ): 1.32 (3H, t), 2.34 (3H, s), 4.34 (2H , q), 8.06-8.07 (1H, m), 8.41-8.43 (1H, m). [Ref: Yamamoto S. et al, Bioorg. Med. Chem. 2012, 20, 422-434.]

References

[1] Patent: WO2016/55791, 2016, A1. Location in patent: Page/Page column 12
[2] Patent: WO2017/175000, 2017, A1. Location in patent: Page/Page column 28

Ethyl 2-chloro-5-Methylnicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-chloro-5-Methylnicotinate Suppliers

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894074-85-2, Ethyl 2-chloro-5-MethylnicotinateRelated Search:

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Ethyl 2-chloro-5-Methylnicotinate

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ethyl 2-chloro-5-methyl-pyridine-3-carboxylate

894074-85-2