Ethyl 2-chloro-5-Methylnicotinate
- Product Name
- Ethyl 2-chloro-5-Methylnicotinate
- CAS No.
- 894074-85-2
- Chemical Name
- Ethyl 2-chloro-5-Methylnicotinate
- Synonyms
- Ethyl 2-chloro-5-Methylnicotinate;ethyl 2-chloro-5-methyl-pyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-chloro-5-methyl-, ethyl ester
- CBNumber
- CB82665841
- Molecular Formula
- C9H10ClNO2
- Formula Weight
- 199.63
- MOL File
- 894074-85-2.mol
Ethyl 2-chloro-5-Methylnicotinate Property
- Boiling point:
- 285.7±35.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.92±0.10(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- HCH0368760
- Product name
- ETHYL-2-CHLORO-5-METHYLNICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.35
- Updated
- 2021/12/16
- Product number
- 4795AC
- Product name
- Ethyl2-chloro-5-methylnicotinate
- Packaging
- 25g
- Price
- $3594
- Updated
- 2021/12/16
- Product number
- CM126212
- Product name
- ethyl2-chloro-5-methylnicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $737
- Updated
- 2021/12/16
- Product number
- CD11026563
- Product name
- Ethyl2-chloro-5-methylnicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- A238502
- Product name
- Ethyl2-chloro-5-methylnicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $940
- Updated
- 2021/12/16
Ethyl 2-chloro-5-Methylnicotinate Chemical Properties,Usage,Production
Synthesis
64-17-5
66909-30-6
894074-85-2
General procedure for the synthesis of ethyl 2-chloro-5-methylnicotinate from ethanol and 2-chloro-5-methylnicotinic acid: to a solution of 2-chloro-5-methylnicotinic acid (3.90 g, 22.7 mmol) in dichloromethane (DCM, 100 mL) was added oxaloyl chloride (9.95 mL, 114 mmol) followed by 1 drop of N,N-dimethylformamide (DMF). The reaction mixture was stirred at room temperature for 30 min, followed by evaporation of the solvent under vacuum. The resulting residue was dissolved in ethanol (EtOH, 66 mL) and stirring was continued for 2 h, after which the solvent was again evaporated under vacuum. The crude product was purified by fast column chromatography (silica gel SiO2, 120 g, eluent was a gradient solution of 0-50% dichloromethane in isohexane) to afford the target compound ethyl 2-chloro-5-methylnicotinate as a colorless oil (3.71 g, 82% yield).1H NMR (δ): 1.32 (3H, t), 2.34 (3H, s), 4.34 (2H , q), 8.06-8.07 (1H, m), 8.41-8.43 (1H, m). [Ref: Yamamoto S. et al, Bioorg. Med. Chem. 2012, 20, 422-434.]
References
[1] Patent: WO2016/55791, 2016, A1. Location in patent: Page/Page column 12
[2] Patent: WO2017/175000, 2017, A1. Location in patent: Page/Page column 28
Ethyl 2-chloro-5-Methylnicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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