CC401 HCl

Product Name: CC401 HCl
CAS No.: 1438391-30-0
Chemical Name: CC401 HCl
Synonyms: CC-401 (hydrochloride);CC-401 dihydrochloride >=95% (HPLC);CC-401 Hydrochloride, 10 mM in DMSO;CC-401 hydrochloride (CC 401 hydrochloride;CC 401 HYDROCHLORIDE; CC401 HYDROCHLORIDE; CC401 HCL;CC401 Hydrochloride,CC-401,Inhibitor,JNK,CC 401 Hydrochloride,CC 401,CC401,inhibit;3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride;3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole hydrochloride;3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride (1:1)
CBNumber: CB82666606
Molecular Formula: C22H25ClN6O
Formula Weight: 424.9265
MOL File: 1438391-30-0.mol

More

Less

CC401 HCl Property

storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (235.33 mM; Need ultrasonic)
form: White powder.
color: White to off-white
Water Solubility: H2O: 10mg/mL, clear

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1613
Product name: CC-401 dihydrochloride
Purity: ≥95% (HPLC)
Packaging: 5 mg
Price: $238.45
Updated: 2025/07/31

AK Scientific

Product number: SYN1028
Product name: CC-401HCl
Packaging: 1mg
Price: $135
Updated: 2021/12/16

ApexBio Technology

Product number: A3287
Product name: CC-401hydrochloride
Packaging: 2mg
Price: $147
Updated: 2021/12/16

ChemScene

Product number: CS-0261
Product name: CC-401hydrochloride
Purity: 99.96%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: A3287
Product name: CC-401hydrochloride
Packaging: 5mg
Price: $219
Updated: 2021/12/16

More

Less

CC401 HCl Chemical Properties,Usage,Production

Uses

CC-401 inhibits c-JUN N-terminal kinases (JNKs) by binding to its ATP-binding site. JNKs belong to the MAP kinase family and respond to stress signals such as heat, cytokines, and osmotic shock.

Biological Activity

CC-401 is a cell penetrant, potent and selective c-Jun N terminal kinase (JNK) inhibitor th at blocks JNK signaling in the r at obstructed kidney and inhibits renal fibrosis in the unilateral ureteral obstruction model. CC-401 in combination with chemotherapy exhibits synergism in colon cancer cell lines.

in vivo

The staining of p-JNK is moderately induced in bevazicumab and Oxaliplatin treatments as compared to control, and in the CC-401-treated samples p-cJun content is significantly lower, consistent with effective JNK inhibition. DNA damage is modestly elevated in combined treatments with CC-401^[2]. CC-401 treatment from days 7 to 24 slows the progression of proteinuria, which is significantly reduced compared to the no-treatment and vehicle groups at days 14 and 21. However, there is still an increase in the degree of proteinuria at day 21 in CC-401-treated rats compared to proteinuria at day 5. The vehicle and no-treatment groups developed renal impairment at day 24 as shown by an increase in serum creatinine. This is prevented by CC-401 treatment^[3].

IC 50

JNK: 25-50 nM (Ki)

CC401 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CC401 HCl Suppliers

China 58 India 1 United Kingdom 1 United States 13 Global 73

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

1438391-30-0, CC401 HClRelated Search:

Acetyl chloride 3-Methylpiperidin-3-ol HCl Binimetinib BKM120 (NVP-BKM120, Buparlisib) Tivozanib (5-METHYL-1H-PYRAZOL-3-YL)-(2-PHENYLQUINAZOLIN-4-YL)AMINE HYDROXY PENTOXIFYLLINE Cabozantinib Dacomitinib (PF299804) AKTI-1/2 PLX4032

CC-401 (hydrochloride)

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride (1:1)

CC 401 HYDROCHLORIDE; CC401 HYDROCHLORIDE; CC401 HCL

CC-401 dihydrochloride >=95% (HPLC)

3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole hydrochloride

CC401 Hydrochloride,CC-401,Inhibitor,JNK,CC 401 Hydrochloride,CC 401,CC401,inhibit

3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride

CC-401 Hydrochloride, 10 mM in DMSO

CC-401 hydrochloride (CC 401 hydrochloride

1438391-30-0

C22H24N6OHCl

API