HYDROXY PENTOXIFYLLINE
- Product Name
- HYDROXY PENTOXIFYLLINE
- CAS No.
- 6493-06-7
- Chemical Name
- HYDROXY PENTOXIFYLLINE
- Synonyms
- LISOFYLLINE;(±)-Lisofylline;(+/-)-LISOFYLLINE;Penthydroxifillyne;Lisofylline (racemic);HYDROXY PENTOXIFYLLINE;5-Hydroxy pentoxifylline;pentoxyfylline metabolite 2;(±)-Lisofylline, 10 mM in DMSO;Hydroxy Pentoxifylline (rac-Lisofylline)
- CBNumber
- CB7385818
- Molecular Formula
- C13H20N4O3
- Formula Weight
- 280.32
- MOL File
- 6493-06-7.mol
HYDROXY PENTOXIFYLLINE Property
- Melting point:
- 123-125°C
- Boiling point:
- 511.2±56.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO: soluble
- form
- solid
- pka
- 15.22±0.20(Predicted)
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
- InChI
- InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
- InChIKey
- NSMXQKNUPPXBRG-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(N(C)C(=O)N(CCCCC(O)C)C2=O)N=C1
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 10010785
- Product name
- (±)-Lisofylline
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 10010785
- Product name
- (±)-Lisofylline
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 10010785
- Product name
- (±)-Lisofylline
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 10010785
- Product name
- (±)-Lisofylline
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $389
- Updated
- 2024/03/01
- Product number
- L469050
- Product name
- (+/-)-Lisofylline
- Packaging
- 50mg
- Price
- $205
- Updated
- 2021/12/16
HYDROXY PENTOXIFYLLINE Chemical Properties,Usage,Production
Description
Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production.1 Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice.2 Lisofylline reduces LPS-induced TNF alpha levels in CD-1 mice.3?Cell permeable.
Chemical Properties
White Solid
Uses
A major oxidative metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig.
Definition
ChEBI: 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione is a dimethylxanthine that is 3,7-dihydro-1H-purine-2,6-dione which is substituted at positions 1,3 and 7 by a 5-hydroxyhexyl group, methyl group and methyl group, respectively. It is a secondary alcohol and a dimethylxanthine.
brand name
ProTec (Cell Therapeutics).
in vitro
(±)-lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. (±)-lisofylline could also suppress the production of the proinflammatory cytokine ifn-γ, inhibit il-12-mediated stat-4 activation, as well as enhance glucose-stimulated β-cell insulin secretion [1].
in vivo
in a previous study, lisofylline was administered to female non-obese diabetic mice for 3 weeks. cytokines and blood glucose concentrations were monitored. histology and immunohistochemistry were also carried out in pancreatic sections. results showed that lisofylline was able to suppress ifn-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes [1].
References
[1] ZANDONG YANG Jerry L N Meng Chen. Lisofylline: a potential lead for the treatment of diabetes[J]. Biochemical pharmacology, 2005, 69 1: Pages 1-5. DOI:10.1016/j.bcp.2004.08.012
[2] Z-D YANG. The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice.[J]. Diabetologia, 2002, 45 9: 1307-1314. DOI:10.1007/s00125-002-0901-y
[3] WYSKA E. Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide.[J]. Pharmacology, 2010, 85 5: 264-271. DOI:10.1159/000288734
HYDROXY PENTOXIFYLLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from HYDROXY PENTOXIFYLLINE manufacturers
- Product
- Hydroxy Pentoxifylline 6493-06-7
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-03-28