AKTI-1/2

Product Name: AKTI-1/2
CAS No.: 612847-09-3
Chemical Name: AKTI-1/2
Synonyms: CS-1595;AKT-IN-VIII;VIIIAKT Inhibitor VIII;AKT inhibitor VIII (AKTI-1/2);Akti-1/2 (AKT inhibitor VIII);Akt Inhibitor VIII, Isozyme-Selective;Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2;AKT inhibitor VIII,PKB,Inhibitor,Akt,Apoptosis,Protein kinase B,inhibit;Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem;1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol
CBNumber: CB1500648
Molecular Formula: C34H29N7O
Formula Weight: 551.64
MOL File: 612847-09-3.mol

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AKTI-1/2 Property

Melting point:: 242-245°C (dec.)
Density: 1.350±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: insoluble in H2O; insoluble in EtOH; ≥9.2 mg/mL in DMSO
pka: 7.49±0.50(Predicted)
form: Yellow solid
color: White to Yellow to Orange
CAS DataBase Reference: 612847-09-3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 124018
Product name: Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
Packaging: 1mg
Price: $264
Updated: 2024/03/01

Sigma-Aldrich

Product number: 124018
Product name: Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
Packaging: 5mg
Price: $309
Updated: 2024/03/01

TCI Chemical

Product number: A3153
Product name: AKT Inhibitor VIII
Packaging: 25MG
Price: $290
Updated: 2023/01/07

TCI Chemical

Product number: A3153
Product name: AKT Inhibitor VIII
Packaging: 100MG
Price: $799
Updated: 2023/01/07

Cayman Chemical

Product number: 14870
Product name: Akt Inhibitor VIII
Purity: ≥98%
Packaging: 500μg
Price: $29
Updated: 2024/03/01

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AKTI-1/2 Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

AKTI-1/2 is a Allosteric Akt (PKB) inhibitors used in synergistic combination therapy for the treatment of cancer.

Definition

ChEBI: 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]-4-piperidinyl]-1H-benzimidazol-2-one is a member of piperidines.

Biological Activity

akt inhibitor viii is a cell-permeable, reversible and potent, selective inhibitor of akt1, akt2 and akt3 with ic50 values of 58 nm, 210 nm and 2.12 μm, respectively.akt inhibitor viii has shown to remarkably increase anti-proliferation induced by furanodiene in human breast cancer cell mcf-7. akt inhibitor viii could enhance the furanodiene- stimulated akt and p-akt expression decreases as well as increase furanodiene-induced parp cleavage in mcf-7 cells [1].akt inhibitor viii has been revealed to inhibit igf-1-induced akt phosphorylation in a concentration-dependent manner. akt inhibitor viii has also been demonstrated to reduce pras40 phosphorylation in pc12 cells [2].

Enzyme inhibitor

This dual Akt1/Akt2 inhibitor (FW = 551.64 g/mol; CAS 612847-09-3; Soluble to 20 mM in DMSO with gentle warming), also named 1,3- dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]- methyl]-4-piperidinyl]-2H-benzimidazol-2-one, targets Protein kinase B (PKB) isoforms Akt1 (IC50 = 50 nM) and Akt2 (IC50 = 210 nM), serine/threonine-specific protein kinases that play a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akti-1/2 is selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. It also sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Complete inhibition is achieved in liver cells treated with 1-10 μM. Akti-1/2 also blocks insulin regulation of PEP carboxykinase and glucose 6-phosphatase expression.

storage

Store at -20°C

References

[1] zhong z1, dang y, yuan x, guo w, li y, tan w, cui j, lu j, zhang q, chen x, wang y. furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. cell physiol biochem. 2012;30(3):778-90.
[2] wang h1, zhang q, zhang l, little pj, xie x, meng q, ren y, zhou l, gao g, quirion r, zheng w. insulin-like growth factor-1 induces the phosphorylation of pras40 via the pi3k/akt signaling pathway in pc12 cells. neurosci lett. 2012 may 10;516(1):105-9.

AKTI-1/2 Preparation Products And Raw materials

Raw materials

Preparation Products

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AKTI-1/2 Suppliers

Americas 1 Canada 1 China 80 Europe 1 India 2 Japan 1 United Kingdom 2 United States 15 Global 103

Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
Email: sales@boylechem.com
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
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Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
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Email: sales@fartop.net
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
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Country: China
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
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Email: Sales-JP@TCIchemicals.com
Country: Japan
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TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
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TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23662
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View Lastest Price from AKTI-1/2 manufacturers

Career Henan Chemical Co

Product: AKTI-1/2 612847-09-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

612847-09-3, AKTI-1/2Related Search:

HYDROXY PENTOXIFYLLINE Cabozantinib Dacomitinib (PF299804) PLX4032 Benzhydrylamine TPP N,N'-Diphenylurea Phenylphosphonic dichloride Dihydroxybenzoic acid 4'-Hydroxyacetophenone Xylene CC401 HCl Binimetinib BKM120 (NVP-BKM120, Buparlisib) Tivozanib (5-METHYL-1H-PYRAZOL-3-YL)-(2-PHENYLQUINAZOLIN-4-YL)AMINE 1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE AKTI-1/2

3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem

CS-1595

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-on

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-γ],guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

2H-BenziMidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-iMidazo[4,5-g]quinoxalin-7-yl)phenyl]Methyl]-4-piperidinyl]-

AKT inhibitor VIII (AKTI-1/2)

1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol-2(

1-(1-(4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2

Akt Inhibitor VIII, Isozyme-Selective

1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol

AKT-IN-VIII

VIIIAKT Inhibitor VIII

Akti-1/2 (AKT inhibitor VIII)

AKT inhibitor VIII,PKB,Inhibitor,Akt,Apoptosis,Protein kinase B,inhibit

612847-09-3

C34H29N7O

Inhibitors

All Inhibitors