AKTI-1/2
- Product Name
- AKTI-1/2
- CAS No.
- 612847-09-3
- Chemical Name
- AKTI-1/2
- Synonyms
- CS-1595;AKT-IN-VIII;VIIIAKT Inhibitor VIII;AKT inhibitor VIII (AKTI-1/2);Akti-1/2 (AKT inhibitor VIII);Akt Inhibitor VIII, Isozyme-Selective;Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2;Akt Inhibitor (Akti-1/2), Akt1/2 kinase inhibitor;AKT inhibitor VIII,PKB,Inhibitor,Akt,Apoptosis,Protein kinase B,inhibit;Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
- CBNumber
- CB1500648
- Molecular Formula
- C34H29N7O
- Formula Weight
- 551.64
- MOL File
- 612847-09-3.mol
AKTI-1/2 Property
- Melting point:
- 242-245°C (dec.)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- insoluble in H2O; insoluble in EtOH; ≥9.2 mg/mL in DMSO
- pka
- 7.49±0.50(Predicted)
- form
- Yellow solid
- color
- White to Yellow to Orange
- CAS DataBase Reference
- 612847-09-3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 124018
- Product name
- Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
- Packaging
- 1mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- 124018
- Product name
- Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
- Packaging
- 5mg
- Price
- $309
- Updated
- 2024/03/01
- Product number
- A3153
- Product name
- AKT Inhibitor VIII
- Packaging
- 25MG
- Price
- $290
- Updated
- 2023/01/07
- Product number
- A3153
- Product name
- AKT Inhibitor VIII
- Packaging
- 100MG
- Price
- $799
- Updated
- 2023/01/07
- Product number
- 14870
- Product name
- Akt Inhibitor VIII
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $29
- Updated
- 2024/03/01
AKTI-1/2 Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
AKTI-1/2 is a Allosteric Akt (PKB) inhibitors used in synergistic combination therapy for the treatment of cancer.
Definition
ChEBI: 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]-4-piperidinyl]-1H-benzimidazol-2-one is a member of piperidines.
Biological Activity
akt inhibitor viii is a cell-permeable, reversible and potent, selective inhibitor of akt1, akt2 and akt3 with ic50 values of 58 nm, 210 nm and 2.12 μm, respectively.akt inhibitor viii has shown to remarkably increase anti-proliferation induced by furanodiene in human breast cancer cell mcf-7. akt inhibitor viii could enhance the furanodiene- stimulated akt and p-akt expression decreases as well as increase furanodiene-induced parp cleavage in mcf-7 cells [1].akt inhibitor viii has been revealed to inhibit igf-1-induced akt phosphorylation in a concentration-dependent manner. akt inhibitor viii has also been demonstrated to reduce pras40 phosphorylation in pc12 cells [2].
Enzyme inhibitor
This dual Akt1/Akt2 inhibitor (FW = 551.64 g/mol; CAS 612847-09-3; Soluble to 20 mM in DMSO with gentle warming), also named 1,3- dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]- methyl]-4-piperidinyl]-2H-benzimidazol-2-one, targets Protein kinase B (PKB) isoforms Akt1 (IC50 = 50 nM) and Akt2 (IC50 = 210 nM), serine/threonine-specific protein kinases that play a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akti-1/2 is selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. It also sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Complete inhibition is achieved in liver cells treated with 1-10 μM. Akti-1/2 also blocks insulin regulation of PEP carboxykinase and glucose 6-phosphatase expression.
storage
Store at -20°C
References
[1] zhong z1, dang y, yuan x, guo w, li y, tan w, cui j, lu j, zhang q, chen x, wang y. furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. cell physiol biochem. 2012;30(3):778-90.
[2] wang h1, zhang q, zhang l, little pj, xie x, meng q, ren y, zhou l, gao g, quirion r, zheng w. insulin-like growth factor-1 induces the phosphorylation of pras40 via the pi3k/akt signaling pathway in pc12 cells. neurosci lett. 2012 may 10;516(1):105-9.
AKTI-1/2 Preparation Products And Raw materials
Raw materials
Preparation Products
AKTI-1/2 Suppliers
- Tel
- --
- Fax
- --
- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58
View Lastest Price from AKTI-1/2 manufacturers
- Product
- AKTI-1/2 612847-09-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23