ChemicalBook > CAS DataBase List > HYDROXY PENTOXIFYLLINE

HYDROXY PENTOXIFYLLINE

Product Name: HYDROXY PENTOXIFYLLINE
CAS No.: 6493-06-7
Chemical Name: HYDROXY PENTOXIFYLLINE
Synonyms: LISOFYLLINE;(±)-Lisofylline;(+/-)-LISOFYLLINE;Penthydroxifillyne;Lisofylline (racemic);HYDROXY PENTOXIFYLLINE;5-Hydroxy pentoxifylline;pentoxyfylline metabolite 2;(±)-Lisofylline, 10 mM in DMSO;Hydroxy Pentoxifylline (rac-Lisofylline)
CBNumber: CB7385818
Molecular Formula: C13H20N4O3
Formula Weight: 280.32
MOL File: 6493-06-7.mol

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HYDROXY PENTOXIFYLLINE Property

Melting point:: 123-125°C
Boiling point:: 511.2±56.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO: soluble
form: solid
pka: 15.22±0.20(Predicted)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI: InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
InChIKey: NSMXQKNUPPXBRG-UHFFFAOYSA-N
SMILES: N1(C)C2=C(N(C)C(=O)N(CCCCC(O)C)C2=O)N=C1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010785
Product name: (±)-Lisofylline
Purity: ≥98%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10010785
Product name: (±)-Lisofylline
Purity: ≥98%
Packaging: 25mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 10010785
Product name: (±)-Lisofylline
Purity: ≥98%
Packaging: 50mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 10010785
Product name: (±)-Lisofylline
Purity: ≥98%
Packaging: 100mg
Price: $389
Updated: 2024/03/01

TRC

Product number: L469050
Product name: (+/-)-Lisofylline
Packaging: 50mg
Price: $205
Updated: 2021/12/16

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HYDROXY PENTOXIFYLLINE Chemical Properties,Usage,Production

Description

Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production.1 Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice.2 Lisofylline reduces LPS-induced TNF alpha levels in CD-1 mice.3?Cell permeable.

Chemical Properties

White Solid

Uses

A major oxidative metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig.

Definition

ChEBI: 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione is a dimethylxanthine that is 3,7-dihydro-1H-purine-2,6-dione which is substituted at positions 1,3 and 7 by a 5-hydroxyhexyl group, methyl group and methyl group, respectively. It is a secondary alcohol and a dimethylxanthine.

brand name

ProTec (Cell Therapeutics).

in vitro

(±)-lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. (±)-lisofylline could also suppress the production of the proinflammatory cytokine ifn-γ, inhibit il-12-mediated stat-4 activation, as well as enhance glucose-stimulated β-cell insulin secretion [1].

in vivo

in a previous study, lisofylline was administered to female non-obese diabetic mice for 3 weeks. cytokines and blood glucose concentrations were monitored. histology and immunohistochemistry were also carried out in pancreatic sections. results showed that lisofylline was able to suppress ifn-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes [1].

References

[1] ZANDONG YANG Jerry L N Meng Chen. Lisofylline: a potential lead for the treatment of diabetes[J]. Biochemical pharmacology, 2005, 69 1: Pages 1-5. DOI:10.1016/j.bcp.2004.08.012
[2] Z-D YANG. The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice.[J]. Diabetologia, 2002, 45 9: 1307-1314. DOI:10.1007/s00125-002-0901-y
[3] WYSKA E. Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide.[J]. Pharmacology, 2010, 85 5: 264-271. DOI:10.1159/000288734

HYDROXY PENTOXIFYLLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HYDROXY PENTOXIFYLLINE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Hydroxy Pentoxifylline 6493-06-7
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-03-28

6493-06-7, HYDROXY PENTOXIFYLLINERelated Search:

Cabozantinib Dacomitinib (PF299804) AKTI-1/2 PLX4032 Theophylline 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Doxofylline Aminophylline CC401 HCl Binimetinib BKM120 (NVP-BKM120, Buparlisib) Tivozanib (5-METHYL-1H-PYRAZOL-3-YL)-(2-PHENYLQUINAZOLIN-4-YL)AMINE HYDROXY PENTOXIFYLLINE Torbafylline 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione HYDROXY PENTOXIFYLLINE-D3 Hydroxy Pentoxifylline-d6

(+/-)-LISOFYLLINE

LISOFYLLINE

pentoxyfylline metabolite 2

HYDROXY PENTOXIFYLLINE

(+/-)-1-(5-HYDROXYHEXYL)-3,7-DIMETHYLXANTHINE

1-(5-Hydroxyhexyl)-3,7-dimethyl-1,2,3,6-tetrahydro-7H-purine-2,6-dione

Penthydroxifillyne

3,7-Dihydro-1-(5-hydroxyhexyl)-3,7-diMethyl-

5-Hydroxy pentoxifylline

Hydroxy Pentoxifylline (rac-Lisofylline)

1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-

Pentoxifylline Impurity 16 ((+/-)-Lisofylline)

Hydroxy PentoxifyllineQ: What is Hydroxy Pentoxifylline Q: What is the CAS Number of Hydroxy Pentoxifylline Q: What is the storage condition of Hydroxy Pentoxifylline Q: What are the applications of Hydroxy Pentoxifylline

Lisofylline (racemic)

1-(5-hydroxyhexyl)-3,7-dimethylxanthine, pentoxyfylline metabolite 2

1-(5-hydroxyhexyl)-3,7-dimethylxanthine, pentoxyfylline metabolite 2/(±)-Lisofylline

1-(5-hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione

phosphatidic acid,pro-inflammatory cytokines,(±)-Lisofylline,inhibit,(±)Lisofylline,(±) Lisofylline,Inhibitor,free fatty acids,(±)-Lisophylline,Type 1 diabetes

(±)-Lisofylline, Anti-inflammatory agent

(±)-Lisofylline, 10 mM in DMSO

(±)-Lisofylline

1-(5-Hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione

6493-06-7

6493-6-7

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