GZD 824

ChemicalBook > CAS DataBase List > GZD 824

Product Name: GZD 824
CAS No.: 1257628-77-5
Chemical Name: GZD 824
Synonyms: GZD824;GZD8824;GZD-824;GZD 824;GZD-824 Free;Olverembatinib;GZD 824 USP/EP/BP;GZD824;GZD-824;GZD 824;Olverembatinib (GZD824);GZD-824; GZD 824;BENZAMIDE
CBNumber: CB82666626
Molecular Formula: C29H27F3N6O
Formula Weight: 532.56
MOL File: 1257628-77-5.mol

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GZD 824 Property

Boiling point:: 630.4±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (187.77 mM)
form: A crystalline solid
pka: 9.04±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21508
Product name: GZD-824
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21508
Product name: GZD-824
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21508
Product name: GZD-824
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 21508
Product name: GZD-824
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: G932028
Product name: GZD824
Packaging: 10mg
Price: $195
Updated: 2021/12/16

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GZD 824 Chemical Properties,Usage,Production

Description

GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC₅₀s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/Abl^T315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC₅₀s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.

Uses

GZD824 is a orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) kinases. It is a COVID19-related research product.

GZD 824 Preparation Products And Raw materials

Raw materials

Preparation Products

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GZD 824 Suppliers

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1257628-77-5, GZD 824Related Search:

NS-398 ACTIN FROM RABBIT MUSCLE Nilotinib hydrochloride anhydrous Axitinib Cabozantinib Palbociclib Trametinib Dacomitinib (PF299804) Lenvatinib Tofacitinib

GZD-824; GZD 824;BENZAMIDE

4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide

3-(2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

GZD8824

GZD824;GZD-824;GZD 824

GZD-824 Free

GZD 824

GZD824

GZD-824

Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-

GZD 824 USP/EP/BP

3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Olverembatinib

Olverembatinib (GZD824)

1257628-77-5

257628-77-5

Inhibitors