Nilotinib hydrochloride anhydrous

Product Name: Nilotinib hydrochloride anhydrous
CAS No.: 923288-95-3
Chemical Name: Nilotinib hydrochloride anhydrous
Synonyms: Nilotinib hydrochloride;AMN-107 HCl;Nilotinib HCI;Nilotinib hydrochloride anhydrou;Nilotinib hydrochloride anhydrous;Nilotinib hydrochloride, 10 mM in DMSO;Nilotinib hydrochloride anhydrous USP/EP/BP;4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide hydrochloride (1:1)
CBNumber: CB92676787
Molecular Formula: C28H23ClF3N7O
Formula Weight: 565.99
MOL File: 923288-95-3.mol

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Nilotinib hydrochloride anhydrous Property

storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (176.68 mM);Ethanol: 2 mg/mL (3.53 mM)
Water Solubility: Water: Insoluble
InChIKey: VTGGYCCJUPYZSX-UHFFFAOYSA-N
SMILES: C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H360May damage fertility or the unborn child

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: N465290
Product name: NilotinibHydrochloride
Packaging: 250mg
Price: $205
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0027469
Product name: NILOTINIB HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $452.67
Updated: 2021/12/16

Axon Medchem

Product number: Axon3168
Product name: Nilotinibhydrochloride-AMN107hydrochloride
Purity: 99%
Packaging: 10mg
Price: $77
Updated: 2021/12/16

Axon Medchem

Product number: Axon3168
Product name: Nilotinibhydrochloride-AMN107hydrochloride
Purity: 99%
Packaging: 50mg
Price: $154
Updated: 2021/12/16

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Nilotinib hydrochloride anhydrous Chemical Properties,Usage,Production

Uses

Nilotinib Hydrochloride might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.

in vivo

Nilotinib hydrochloride (oral gavage, 40 mg/kg, daily, 4 weeks) shows equivalent or higher antitumor effects in BALB/cSLc-nu/nu mice with GIST xenograft^[2].
Nilotinib hydrochloride has a significant healing effect on the macroscopic and microscopic pathologic scores and ensures considerable mucosal healing in the indomethacin-induced enterocolitis rat model while decreases the PDGFR α and β levels and apoptotic scores in the colon^[3].

Animal Model:	BALB/cSLc-nu/nu mice with GIST xenograft (GK1X, GK2X and GK3X)^[2]
Dosage:	40 mg/kg
Administration:	Oral gavage; daily; 4 weeks
Result:	Inhibited tumor growth by 69.6% in GK1X, 85.3% in GK2X and 47.5% in GK3X xenograft line.

Nilotinib hydrochloride anhydrous Preparation Products And Raw materials

Raw materials

Preparation Products

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Nilotinib hydrochloride anhydrous Suppliers

China 56 India 10 Israel 1 United States 5 Global 72

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Porse Fine Chemical Co.,LTD

Tel: 20-66003216 18666003216
Fax: +86-20-28069063
Email: info@porsefinechemical.com
Country: China
ProdList: 1941
Advantage: 62

Nanjing First Pharmaceutical Co., Ltd.

Tel: 025-83172655 13585105703
Fax: +86-25-86501191
Email: sales@njfirstpharm.com
Country: China
ProdList: 110
Advantage: 60

Yangzhou QinYuan Pharmaceutical Co., Ltd.

Tel: 0514-80939770 13773367191
Fax: 0514-82664689
Email: yzqyyykj@163.com
Country: China
ProdList: 252
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

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View Lastest Price from Nilotinib hydrochloride anhydrous manufacturers

Baoji Guokang Healthchem co.,ltd

Product: Nilotinib hydrochloride anhydrous 923288-95-3
Price: US $16.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10kgs
Release date: 2021-06-07

Dideu Industries Group Limited

Product: Nilotinib hydrochloride anhydrous 923288-95-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-18

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Nilotinib hydrochloride anhydrous

Nilotinib hydrochloride

4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide hydrochloride (1:1)

AMN-107 HCl

Nilotinib hydrochloride anhydrou

Nilotinib hydrochloride anhydrous USP/EP/BP

Nilotinib HCI

Nilotinib hydrochloride, 10 mM in DMSO

923288-95-3

C28H23ClF3N7O