LY2334737

ChemicalBook > CAS DataBase List > LY2334737

Product Name: LY2334737
CAS No.: 892128-60-8
Chemical Name: LY2334737
Synonyms: LY2334737;LY 2334737;LY-2334737;LY2334737;2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine;Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-;N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-2-propylpentanamide;N-(1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide;anticancer,HEV,Gemcitabine,HEVs,HRVs,LY 2334737,EV-A71,Rhinovirus,inhibit,Nucleoside Antimetabolite/Analog,Enterovirus,HRV,orally,LY2334737,LY-2334737,antiviral,Inhibitor
CBNumber: CB82668271
Molecular Formula: C17H25F2N3O5
Formula Weight: 389.39
MOL File: 892128-60-8.mol

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LY2334737 Property

Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 9.66±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1815
Product name: LY2334737
Purity: 99.02%
Packaging: 5mg
Price: $283
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BL98401
Product name: LY 2334737
Packaging: 50mg
Price: $402.5
Updated: 2021/12/16

ChemScene

Product number: CS-1815
Product name: LY2334737
Purity: 99.02%
Packaging: 10mg
Price: $432
Updated: 2021/12/16

AK Scientific

Product number: 9607CS
Product name: Cytidine,2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-
Packaging: 50mg
Price: $593
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BL98401
Product name: LY 2334737
Packaging: 10mg
Price: $115
Updated: 2021/12/16

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LY2334737 Chemical Properties,Usage,Production

Biological Activity

ly2334737 is an oral prodrug of gemcitabine, the clinically efficacious anticancer agent [1].ly2334737 has been shown the hydrolytic activity by carboxylesterase 2 (ces2). the michaelis-menten kinetic parameters are exhibited to be : km of 43μm and vmax of 40nmol/min/mg protein. in addition, ly2334737 has been found to be cytotoxic to cells in the ncl-60 panel with the ec50 values of 0.512±0.016μm, 0.402±0.018μm and 0.034±0.002μm for pc-gfp alone, hct-116 mock transfectant and hct-116 ces2 transfectant cell lines, respectively. apart from these, the study result has been noted that parental sk-ov-3 cells were approximately 4-fold more sensitive to ly2334737 cytotoxicity than the sk-ov-3 knockdown with the ec50 values of 1.1μm and 4.5μm, respectively [1].

References

[1] pratt se1, durland-busbice s, shepard rl, heinz-taheny k, iversen pw, dantzig ah. human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (ly2334737) and confers prodrug sensitivity to cancer cells. clin cancer res. 2013 mar 1;19(5):1159-68.

LY2334737 Preparation Products And Raw materials

Raw materials

Preparation Products

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892128-60-8, LY2334737Related Search:

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LY2334737

2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine

LY 2334737;LY-2334737;LY2334737

Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-

anticancer,HEV,Gemcitabine,HEVs,HRVs,LY 2334737,EV-A71,Rhinovirus,inhibit,Nucleoside Antimetabolite/Analog,Enterovirus,HRV,orally,LY2334737,LY-2334737,antiviral,Inhibitor

N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-2-propylpentanamide

N-(1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide

892128-60-8

C17H25F2N3O5