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ZOSUQUIDAR TRIHYSROCHLORIDE

Product Name
ZOSUQUIDAR TRIHYSROCHLORIDE
CAS No.
167465-36-3
Chemical Name
ZOSUQUIDAR TRIHYSROCHLORIDE
Synonyms
LY335979;Trihydrochloride;CS-58;D06387;RS 33295-198;LY335979) 3HCl;Zosuquidar HCl;Zosuquidr.3HCl;Zosuquidar 3HCl;Zosuquidar TriHCl
CBNumber
CB81482979
Molecular Formula
C32H32ClF2N3O2
Formula Weight
564.07
MOL File
167465-36-3.mol
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ZOSUQUIDAR TRIHYSROCHLORIDE Property

Melting point:
172-176°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly), Water (Slightly, Sonicated)
form 
Solid
color 
Pale Yellow to Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21533
Product name
Zosuquidar (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
21533
Product name
Zosuquidar (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
21533
Product name
Zosuquidar (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
21533
Product name
Zosuquidar (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$456
Updated
2024/03/01
Tocris
Product number
5456
Product name
Zosuquidartrihydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$844
Updated
2021/12/16
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ZOSUQUIDAR TRIHYSROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).

Biological Activity

ly335979 is a selective inhibitor of p-gp with ic50 value of 1.2 nm [1, 2].p-gp (p-glycoprotein) is a member of atp-binding cassette (abc) transporters and plays a pivotal role in pumping many foreign substances out of cells. it has been reported that abnormal expression of p-gp is correlated with the multidrug resistance of tumor cells [3].ly335979 is a potent p-gp inhibitor and has a different selectivity with the reported p-gp inhibitor cyclosporin a or verapamil. in drug-resistant cell line hl60/vcr with highly expression of p-gp, ly335979 exhibited highly restore ability of p-gp than cyclosporin a or verapamil and the ic 50 value of 1.2 nm [1]. when tested with a panel of cell lines over-expressed p-gp (cem/vlb100, mcf-7/adr, 2780ad, p388/adr, and ucla-p3.003vlb), administration of ly335979 reversed the cells resistance to vinblastine, doxorubicin, btoposide and taxol by inhibiting p-gp activity [2].in female nude mice model with ucla-p3.003vlb mdr tumor cells subcutaneous xenograft, pre-treated with ly335979 (30mg/kg) restored tumor cells sensitivity to taxol (20 mg/kg) which combination markedly suppressed solid tumor growth compared with control group [2].

storage

Store at -20°C

References

1. green, l.j., p. marder, and c.a. slapak, modulation by ly335979 of p-glycoprotein function in multidrug-resistant cell lines and human natural killer cells. biochem pharmacol, 2001. 61(11): p. 1393-9.2. dantzig, a.h., et al., reversal of p-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, ly335979. cancer res, 1996. 56(18): p. 4171-9.3. hu, t., et al., reversal of p-glycoprotein (p-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of salvia miltiorrhiza. phytomedicine, 2014. 21(11): p. 1264-72.

ZOSUQUIDAR TRIHYSROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ZOSUQUIDAR TRIHYSROCHLORIDE Suppliers

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
960
Advantage
64
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
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View Lastest Price from ZOSUQUIDAR TRIHYSROCHLORIDE manufacturers

Career Henan Chemical Co
Product
ZOSUQUIDAR TRIHYSROCHLORIDE 167465-36-3
Price
US $0.50/g
Min. Order
1g
Purity
98%min
Supply Ability
10g,100g,1kg
Release date
2020-01-09

167465-36-3, ZOSUQUIDAR TRIHYSROCHLORIDERelated Search:


  • Zosuquidar 3HCl
  • Zosuquidar trihydrochloride, >=98%
  • Trihydrochloride
  • Zosuquidar (LY335979) triHydrochloride
  • D06387
  • LY 335979; LY-335979; LY335979; D06387; RS33295198;
  • (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
  • RS-33295-198; ZOSUQUIDAR; LY-335979
  • CS-58
  • LY335979
  • RS 33295-198
  • LY335979 (Zosuquidar 3HCl)
  • ZOSUQUIDAR TRIHYSROCHLORIDE
  • LY335979, RS 33295-198
  • Zosuquidar Trihydrochloride
  • [6(R)-(1aα,6α,10bα)]-4-(1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl)-α-[(5-quinolinyloxy)Methyl]-piperazineethanol trihydrochloride, (2R)-anti-5-{3-[4-(10,11-difluoroMethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy
  • RS-33295-198, ZOSUQUIDAR
  • (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)Methyl]-1-piperazineethanol Hydrochloride
  • LY335979 (Zosuquidar trihydrochloride)
  • (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride
  • Zosuquidar (LY335979
  • 1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-,trihydrochloride
  • RS 33295-198 (D06387) 3HCl
  • (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride Zosuquidar trihydrochloride LY335979
  • Zosuquidar trihydrochloride LY335979
  • Zosuquidr.3HCl(LY335979)
  • Zosuquidar (LY335979) 3HCl
  • LY-335979 trihydrochloride
  • RS 33295-198 trihydrochloride
  • Zosuquidar TriHCl
  • ZOSUQUIDAR TRIHYSROCHLORIDE USP/EP/BP
  • 1-Piperazineethanol,4-[(1aa,6a,10ba)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-a-[(5-quinolinyloxy)methyl]-,hydrochloride (1:3), (aR)-
  • LY335979) 3HCl
  • Zosuquidar (RS 33295-198
  • Zosuquidar HCl
  • Zosuquidr.3HCl
  • (R)-1-(4-((1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride
  • Zosuquidar trihydrochloride 3HCL
  • CEM/VLB100,Pgp,2780AD,Multidrug resistance protein 1,CD243,anti-tumor activity,P388/ADR,P-glycoprotein,UCLA-P3.003VLB,2780,ABCB1,MCF7,acute myelogenous leukemia,MDR1,HL60,P-gp,UCLA-P3,P388,MCF7/ADR,CCRF-CEM,K562,Inhibitor,Zosuquidar trihydrochloride,Cluster of differentiation 243,AML,inhibit
  • LY335979(Zosuquidar)/Zosuquidar trihydrochloride, RS-33295-198
  • 4-piperazin-1-ylpyrrolidin-2-one
  • 1-(3-aminocyclopentyl)-N,N-dimethyl-pyrrolidin-3-amine
  • Levodropropizine Impurity 12
  • N'-(3-pyridylmethyl)butane-1,4-diamine
  • methyl (4R)-4-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-[4-(3-pyridylmethylamino)butylamino]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
  • 167465-36-3
  • C32H31F2N3O23HCl
  • C32H34Cl3F2N3O2
  • C32H31F2N3O23ClH
  • Inhibitors
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals