TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
- Product Name
- TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
- CAS No.
- 264916-06-5
- Chemical Name
- TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
- Synonyms
- tert-butyl 5-aMinoisoin;2-Boc-5-aminoisoindoline;5-Amino-2-(tert-butoxycarbonyl)isoindoline;TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE;1,2-Benzenediol,4-[4-(cyclopentyloxy)-5-quinolinyl]-;tert-butyl 5-amino-1,3-dihydroisoindole-2-carboxylate;5-Aminoisoindoline-2-carboxylic acid tert-butyl ester;tert-butyl 5-aMino-2,3-dihydro-1H-isoindole-2-carboxylate;5-Amino-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester;5-Amino-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester
- CBNumber
- CB8266903
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 264916-06-5.mol
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Property
- Boiling point:
- 376.3±42.0 °C(Predicted)
- Density
- 1.177
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.76±0.20(Predicted)
- Appearance
- Yellow to brown Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- Z4521
- Product name
- tert-Butyl5-aminoisoindoline-2-carboxylate
- Packaging
- 250mg
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 118980
- Product name
- tert-Butyl5-aminoisoindoline-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- Z4521
- Product name
- tert-Butyl5-aminoisoindoline-2-carboxylate
- Packaging
- 1g
- Price
- $328
- Updated
- 2021/12/16
- Product number
- CHM0290732
- Product name
- TERT-BUTYL-5-AMINOISOINDOLINE-2-CARBOXYLATE
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $497.93
- Updated
- 2021/12/16
- Product number
- 118980
- Product name
- tert-Butyl5-aminoisoindoline-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $720
- Updated
- 2021/12/16
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
400727-63-1
264916-06-5
General procedure for the synthesis of tert-butyl 5-aminoisoindoline-2-carboxylate from tert-butyl 5-nitroisoindoline-2-carboxylate: In a 100 mL single-necked round-bottom flask equipped with a magnetic stirrer, tert-butyl 5-nitroisoindoline-2-carboxylate (650 mg, 2.5 mmol) and anhydrous ethanol (50 mL) were added. Palladium/carbon catalyst (160 mg) was added to the reaction mixture and the hydrogenation reaction was carried out at room temperature for 15 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product tert-butyl 5-aminoisoindole-2-carboxylate (585 mg, 99% yield) as a yellow oil. The product could be used in subsequent steps without further purification. Mass spectrometry result: [M + H]+ 179.
References
[1] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 331
[2] Patent: WO2016/90079, 2016, A1. Location in patent: Paragraph 00326-00327
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5533 - 5535
[4] Russian Journal of Organic Chemistry, 2006, vol. 42, # 8, p. 1174 - 1182
[5] Patent: WO2011/17296, 2011, A1. Location in patent: Page/Page column 47
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Suppliers
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View Lastest Price from TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE manufacturers
- Product
- TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE 264916-06-5
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10