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TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE

Product Name
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
CAS No.
264916-06-5
Chemical Name
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
Synonyms
tert-butyl 5-aMinoisoin;2-Boc-5-aminoisoindoline;5-Amino-2-(tert-butoxycarbonyl)isoindoline;TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE;1,2-Benzenediol,4-[4-(cyclopentyloxy)-5-quinolinyl]-;tert-butyl 5-amino-1,3-dihydroisoindole-2-carboxylate;5-Aminoisoindoline-2-carboxylic acid tert-butyl ester;tert-butyl 5-aMino-2,3-dihydro-1H-isoindole-2-carboxylate;5-Amino-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester;5-Amino-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester
CBNumber
CB8266903
Molecular Formula
C13H18N2O2
Formula Weight
234.29
MOL File
264916-06-5.mol
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TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Property

Boiling point:
376.3±42.0 °C(Predicted)
Density 
1.177
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
4.76±0.20(Predicted)
Appearance
Yellow to brown Solid-Liquid Mixture
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

AK Scientific
Product number
Z4521
Product name
tert-Butyl5-aminoisoindoline-2-carboxylate
Packaging
250mg
Price
$169
Updated
2021/12/16
Matrix Scientific
Product number
118980
Product name
tert-Butyl5-aminoisoindoline-2-carboxylate
Purity
95+%
Packaging
250mg
Price
$288
Updated
2021/12/16
AK Scientific
Product number
Z4521
Product name
tert-Butyl5-aminoisoindoline-2-carboxylate
Packaging
1g
Price
$328
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0290732
Product name
TERT-BUTYL-5-AMINOISOINDOLINE-2-CARBOXYLATE
Purity
98.00%
Packaging
5MG
Price
$497.93
Updated
2021/12/16
Matrix Scientific
Product number
118980
Product name
tert-Butyl5-aminoisoindoline-2-carboxylate
Purity
95+%
Packaging
1g
Price
$720
Updated
2021/12/16
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TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

400727-63-1

264916-06-5

General procedure for the synthesis of tert-butyl 5-aminoisoindoline-2-carboxylate from tert-butyl 5-nitroisoindoline-2-carboxylate: In a 100 mL single-necked round-bottom flask equipped with a magnetic stirrer, tert-butyl 5-nitroisoindoline-2-carboxylate (650 mg, 2.5 mmol) and anhydrous ethanol (50 mL) were added. Palladium/carbon catalyst (160 mg) was added to the reaction mixture and the hydrogenation reaction was carried out at room temperature for 15 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product tert-butyl 5-aminoisoindole-2-carboxylate (585 mg, 99% yield) as a yellow oil. The product could be used in subsequent steps without further purification. Mass spectrometry result: [M + H]+ 179.

References

[1] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 331
[2] Patent: WO2016/90079, 2016, A1. Location in patent: Paragraph 00326-00327
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5533 - 5535
[4] Russian Journal of Organic Chemistry, 2006, vol. 42, # 8, p. 1174 - 1182
[5] Patent: WO2011/17296, 2011, A1. Location in patent: Page/Page column 47

TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE Suppliers

China 81 Germany 1 India 1 United States 8 Global 91
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
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View Lastest Price from TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE manufacturers

Career Henan Chemical Co
Product
TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE 264916-06-5
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-10

264916-06-5, TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATERelated Search:

T-BUTYL 4-BROMOBUTYRATE TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE tert-Butyl 3-aminobenzylcarbamate

  • 5-Amino-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester
  • 5-Amino-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester
  • 5-Amino-2-(tert-butoxycarbonyl)isoindoline
  • 5-Aminoisoindoline-2-carboxylic acid tert-butyl ester
  • tert-butyl 5-aMinoisoin
  • tert-butyl 5-aMino-2,3-dihydro-1H-isoindole-2-carboxylate
  • TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
  • tert-butyl 5-amino-1,3-dihydroisoindole-2-carboxylate
  • 2H-Isoindole-2-carboxylic acid, 5-amino-1,3-dihydro-, 1,1-dimethylethyl ester
  • 1,2-Benzenediol,4-[4-(cyclopentyloxy)-5-quinolinyl]-
  • 2-Boc-5-aminoisoindoline
  • 264916-06-5