ChemicalBook > CAS DataBase List > 4-fluoro-2-Methoxy-5-nitroaniline

4-fluoro-2-Methoxy-5-nitroaniline

Product Name
4-fluoro-2-Methoxy-5-nitroaniline
CAS No.
1075705-01-9
Chemical Name
4-fluoro-2-Methoxy-5-nitroaniline
Synonyms
4-fluoro-2-methoxy;AZD9291 intermediates;uoro-2-methoxy-5-nitroaniL;4-Fluoro-2-mehoxy-5-nitroaniline;4-fluoro-2-Methoxy-5-nitroaniline;4-fluoro-2-methoxy-5-nitrophenylamine;4-Fluoro-2-Methoxy-5-nitrobenzenaMine;4-Fluoro-2-methoxy-5-nitroaniline 95+%;Benzenamine, 4-fluoro-2-methoxy-5-nitro-;4-fluoro-2-Methoxy-5-nitroaniline ISO 9001：2015 REACH
CBNumber
CB82670450
Molecular Formula
C7H7FN2O3
Formula Weight
186.14
MOL File
1075705-01-9.mol
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4-fluoro-2-Methoxy-5-nitroaniline Property

Melting point:
130 °C
Boiling point:
354.8±37.0 °C(Predicted)
Density 
1.412±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder to crystal
pka
2.31±0.10(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C7H7FN2O3/c1-13-7-2-4(8)6(10(11)12)3-5(7)9/h2-3H,9H2,1H3
InChIKey
FYSIGSQCZXQTIH-UHFFFAOYSA-N
SMILES
C1(N)=CC([N+]([O-])=O)=C(F)C=C1OC
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Safety

HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1246
Product name
4-Fluoro-2-methoxy-5-nitroaniline
Packaging
5G
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
F1246
Product name
4-Fluoro-2-methoxy-5-nitroaniline
Packaging
25G
Price
$98
Updated
2024/03/01
TRC
Product number
F472455
Product name
4-Fluoro-2-methoxy-5-nitroaniline
Packaging
10g
Price
$140
Updated
2021/12/16
TRC
Product number
F472455
Product name
4-Fluoro-2-methoxy-5-nitroaniline
Packaging
25g
Price
$275
Updated
2021/12/16
AK Scientific
Product number
9516AF
Product name
4-Fluoro-2-methoxy-5-nitroaniline
Packaging
100g
Price
$321
Updated
2021/12/16
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4-fluoro-2-Methoxy-5-nitroaniline Chemical Properties,Usage,Production

Uses

4-Fluoro-2-methoxy-5-nitroaniline is used as a reagent for preparing the anticancer drug Mereletinib.

Synthesis

4-FLUORO-2-METHOXYANILINE(551 mg, 3.90 mmol) is dissolved in dichloromethane (39.0 mL), concentrated sulfuric acid (1.85 mL) is added dropwise with stirring under ice-cooling, and then concentrated nitric acid (267 μL, 5.85 mmol) is added dropwise. After stirring for 3 hours under ice-cooling, saturated aqueous sodium bicarbonate was added until pH 8 was reached. After washing with saturated aqueous sodium bicarbonate solution, washing with saturated brine, the organic layer was dried over sodium sulfate and evaporated under reduced pressure to obtain 675 mg of the 4-fluoro-2-Methoxy-5-nitroaniline (yield 93%).

4-fluoro-2-Methoxy-5-nitroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-fluoro-2-Methoxy-5-nitroaniline Suppliers

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View Lastest Price from 4-fluoro-2-Methoxy-5-nitroaniline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-fluoro-2-Methoxy-5-nitroaniline 1075705-01-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-02
Hebei Weibang Biotechnology Co., Ltd
Product
4-fluoro-2-Methoxy-5-nitroaniline 1075705-01-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluoro-2-Methoxy-5-Nitroaniline 1075705-01-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-13

1075705-01-9, 4-fluoro-2-Methoxy-5-nitroanilineRelated Search:

1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

  • 4-fluoro-2-Methoxy-5-nitroaniline
  • 2-Amino-5-fluoro-4-nitroanisole, 4-Fluoro-5-nitro-o-anisidine
  • 4-Fluoro-2-Methoxy-5-nitrobenzenaMine
  • 4-Fluoro-2-methoxy-5-nitroaniline 95+%
  • Benzenamine, 4-fluoro-2-methoxy-5-nitro-
  • 4-fluoro-2-methoxy-5-nitrophenylamine
  • AZD9291 intermediates
  • uoro-2-methoxy-5-nitroaniL
  • 4-Fluoro-2-mehoxy-5-nitroaniline
  • 4-fluoro-2-Methoxy-5-nitroaniline ISO 9001：2015 REACH
  • 4-fluoro-2-methoxy-5-nitroaniline Molecular Formula: C7H7FN2O3 Molecular Weight: 186.14
  • 4-fluoro-2-methoxy
  • 1075705-01-9
  • 075705-01-9
  • AZD9291
  • API
  • 1075705-01-9