4-fluoro-2-Methoxy-5-nitroaniline
- Product Name
- 4-fluoro-2-Methoxy-5-nitroaniline
- CAS No.
- 1075705-01-9
- Chemical Name
- 4-fluoro-2-Methoxy-5-nitroaniline
- Synonyms
- 4-fluoro-2-methoxy;AZD9291 intermediates;uoro-2-methoxy-5-nitroaniL;4-Fluoro-2-mehoxy-5-nitroaniline;4-fluoro-2-Methoxy-5-nitroaniline;4-fluoro-2-methoxy-5-nitrophenylamine;4-Fluoro-2-Methoxy-5-nitrobenzenaMine;4-Fluoro-2-methoxy-5-nitroaniline 95+%;Benzenamine, 4-fluoro-2-methoxy-5-nitro-;4-fluoro-2-Methoxy-5-nitroaniline ISO 9001：2015 REACH
- CBNumber
- CB82670450
- Molecular Formula
- C7H7FN2O3
- Formula Weight
- 186.14
- MOL File
- 1075705-01-9.mol
4-fluoro-2-Methoxy-5-nitroaniline Property
- Melting point:
- 130 °C
- Boiling point:
- 354.8±37.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- 2.31±0.10(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C7H7FN2O3/c1-13-7-2-4(8)6(10(11)12)3-5(7)9/h2-3H,9H2,1H3
- InChIKey
- FYSIGSQCZXQTIH-UHFFFAOYSA-N
- SMILES
- C1(N)=CC([N+]([O-])=O)=C(F)C=C1OC
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F1246
- Product name
- 4-Fluoro-2-methoxy-5-nitroaniline
- Packaging
- 5G
- Price
- $33
- Updated
- 2024/03/01
- Product number
- F1246
- Product name
- 4-Fluoro-2-methoxy-5-nitroaniline
- Packaging
- 25G
- Price
- $98
- Updated
- 2024/03/01
- Product number
- F472455
- Product name
- 4-Fluoro-2-methoxy-5-nitroaniline
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- F472455
- Product name
- 4-Fluoro-2-methoxy-5-nitroaniline
- Packaging
- 25g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 9516AF
- Product name
- 4-Fluoro-2-methoxy-5-nitroaniline
- Packaging
- 100g
- Price
- $321
- Updated
- 2021/12/16
4-fluoro-2-Methoxy-5-nitroaniline Chemical Properties,Usage,Production
Uses
4-Fluoro-2-methoxy-5-nitroaniline is used as a reagent for preparing the anticancer drug Mereletinib.
Synthesis
4-FLUORO-2-METHOXYANILINE(551 mg, 3.90 mmol) is dissolved in dichloromethane (39.0 mL), concentrated sulfuric acid (1.85 mL) is added dropwise with stirring under ice-cooling, and then concentrated nitric acid (267 μL, 5.85 mmol) is added dropwise. After stirring for 3 hours under ice-cooling, saturated aqueous sodium bicarbonate was added until pH 8 was reached. After washing with saturated aqueous sodium bicarbonate solution, washing with saturated brine, the organic layer was dried over sodium sulfate and evaporated under reduced pressure to obtain 675 mg of the 4-fluoro-2-Methoxy-5-nitroaniline (yield 93%).
4-fluoro-2-Methoxy-5-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-fluoro-2-Methoxy-5-nitroaniline Suppliers
View Lastest Price from 4-fluoro-2-Methoxy-5-nitroaniline manufacturers
- Product
- 4-fluoro-2-Methoxy-5-nitroaniline 1075705-01-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-03-08
- Product
- 4-fluoro-2-Methoxy-5-nitroaniline 1075705-01-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 4-Fluoro-2-Methoxy-5-Nitroaniline 1075705-01-9
- Price
- US $50.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2 kg
- Release date
- 2023-01-31