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Metrizamide

Product Name
Metrizamide
CAS No.
31112-62-6
Chemical Name
Metrizamide
Synonyms
amipaque;pyranose;WIN39103;WIN-39103;y-d-glucose;telebrix300;METRIZAMIDE;no)-2-deoxy-;Metrizamide (500 mg);METRIZAMIDE,ULTRAPURE
CBNumber
CB8268280
Molecular Formula
C18H22I3N3O8
Formula Weight
789.1
MOL File
31112-62-6.mol
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Metrizamide Property

Melting point:
222-224°C
alpha 
D20 +18.0° (c = 10% in 0.1N HCl; equilibrated with respect to mutarotation)
Boiling point:
927.4±65.0 °C(Predicted)
Density 
2.0128 (estimate)
storage temp. 
−20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.39±0.46(Predicted)
color 
White to Off-White
Merck 
13,6176
CAS DataBase Reference
31112-62-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
RTECS 
LZ6650000
Toxicity
LD50 i.v. in mice: 15 g/kg (Torsten); 18.6 g/kg (Salveson); 11.5 g/kg (Sovak); 17.3 g/kg (Aspelin)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27724
Product name
Metrizamide
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
27724
Product name
Metrizamide
Packaging
10mg
Price
$347
Updated
2024/03/01
Cayman Chemical
Product number
27724
Product name
Metrizamide
Packaging
5mg
Price
$210
Updated
2024/03/01
TRC
Product number
M338850
Product name
Metrizamide
Packaging
100mg
Price
$1390
Updated
2021/12/16
Biosynth Carbosynth
Product number
MM01350
Product name
Metrizamide
Packaging
1mg
Price
$55
Updated
2021/12/16
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Metrizamide Chemical Properties,Usage,Production

Description

Metrizamide is a non-ionic contrast agent. In vivo, metrizamide (0.1 ml/kg of a 370 mg I/ml solution) does not induce EEG abnormalities, indicating minimal neurotoxicity in rabbits. It has also been used as a solute in gradient centrifugation applications.

Chemical Properties

white fine crystalline powder

Originator

Amipaque,Winthrop laboratories

Uses

Metrizamide is a X-ray contrast agent related to Metrizoic Acid (M338935). Metrizamide is used as a diagnostic aid (radiopaque medium).

Uses

Contrasting product

Uses

Metrizamide is a X-ray contrast agent related to Metrizoic Acid (M338935). Metrizamide is used as an diagnostic aid (radiopaque medium).

Definition

A SUGAR that has a six-membered ring form (five carbon atoms and one oxygen atom).

Definition

pyranose: A sugar having a sixmemberedring containing five carbonatoms and one oxygen atom.

Manufacturing Process

1 mole 3-(acetyl-methyl-amino)-2,4,6-triiodo-5-methylamino-benzoic acid was suspended in thionyl chloride and reacted by stirring at 70°C for 16 hours. Excess thionyl chloride was distilled off in vacuum, the residue dissolved in chloroform, cooled in the ice bath, washed with iced water (3x100 ml), saturated sodium bicarbonate solution (3 x 100 ml), 2 N sodium carbonate solution (2 x 100 ml) and finally with water (3 x 100 ml). After drying with CaCl2 the chloroform distilled off and residue dried in vacuum. Yield of 3- acetylamino-5-(acetyl-methyl-amino)-2,4,6-triiodo-benzoyl chloride: 66%; MP: 238°-240°C (the re-crystallization from tetrahydrofuran).
It (0.02 mole) was dissolved in dioxan (120 ml). To the solution was added (25 ml) and NaHCO3 (0.0022 mol). Glucosamine (0.022 mol) was added in portions and reaction mixture left by stirring at room temperature for 24 hours. The solution was evaporated to dryness in vacuum, the residue dissolved in water (500 ml), filtered clear and run through an Amberlite IR120 H+ ion exchange column. The effluent was evaporated to dryness in vacuum resulting in a white crystalline residue. The crude 3-acetylamino-5-Nmethyl-acetylamino-2,4,6-triiodobenzoyl glucosamine was crystallised from isopropanol (charcoal-treated when in solution), dissolved in water and charcoal-treated at 100°C for 20 min. The water was distilled off in vacuum and the white residue dried in vacuum at 70°C. MP: 190°-195°C.

brand name

Amipaque (GE Healthcare).

Therapeutic Function

Diagnostic aid

Metrizamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Metrizamide Suppliers

SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from Metrizamide manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Metrizamide 31112-62-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
Metrizamide 31112-62-6
Price
US $50.00-15.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-18
Career Henan Chemical Co
Product
Metrizamide 31112-62-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98-99.9%
Supply Ability
100kg
Release date
2020-02-03

31112-62-6, MetrizamideRelated Search:


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  • 2-(3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)benzamido)-2-deoxy-d-gluco
  • 2-(3-acetamido-5-n-methyl-acetamido-2,4,6-triiodobenzamido)-2-deoxy-d-glucos
  • 3-acetylamino-5-n-methyl-acetylamino-2,4,6-triiodobenzoylglucosamine
  • amipaque
  • d-glucose,2-((3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl)ami
  • d-glucose,2-(3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)benzamido)-2-deoxy
  • no)-2-deoxy-
  • pyranose
  • telebrix300
  • y-d-glucose
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