Atglistatin

ChemicalBook > CAS DataBase List > Atglistatin

Product Name: Atglistatin
CAS No.: 1469924-27-3
Chemical Name: Atglistatin
Synonyms: istatin;CS-1024;Atglistatin;At listatin;Atglistatin, >=98%;Atglistatin, 10 mM in DMSO;3-(4'-(DIMETHYLAMINO)BIPHENYL-3-YL)-1,1-DIMETHYLUREA;3-[4’-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea;3-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea;N'-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylurea
CBNumber: CB82685322
Molecular Formula: C17H21N3O
Formula Weight: 283.37
MOL File: 1469924-27-3.mol

Less

Atglistatin Property

Boiling point:: 498.6±45.0 °C(Predicted)
Density: 1.135±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
form: powder
pka: 15.01±0.70(Predicted)
color: white to beige
Stability:: Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 36/37/39

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1075
Product name: Atglistatin
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $115
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1075
Product name: Atglistatin
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $486
Updated: 2023/06/20

Cayman Chemical

Product number: 15284
Product name: Atglistatin
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 15284
Product name: Atglistatin
Purity: ≥95%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 15284
Product name: Atglistatin
Purity: ≥95%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Less

Atglistatin Chemical Properties,Usage,Production

Description

Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, generating diacylglyerol. Atglistatin is a potent, selective, and competitive inhibitor of ATGL (IC₅₀ = 0.7 μM). It does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases. Atglistatin blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo. It does not affect lipolysis in ATGL knockout mice.

Uses

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

Biochem/physiol Actions

Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

References

1) Mayer et al. (2013), Development of small-molecule inhibitors targeting adipose triglyceride lipase; Nat. Chem. Biol. 9 785 2) Zagani et al. (2015) Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells; Oncotarget 6 28282

Atglistatin Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Atglistatin Suppliers

China 122 India 1 United Kingdom 1 United States 18 Global 142

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 997
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4589
Advantage: 55

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1004
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-0512-63009836 15365350169
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3984
Advantage: 60

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1502
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5960
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2946
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7316
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9987
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1925
Advantage: 55

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7570
Advantage: 55

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: +86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 900
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28805
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

ShangHai Book Chemical Co., Ltd.

Tel: 15001988657 15802146997
Email: info@bookchemicals.com
Country: China
ProdList: 1000
Advantage: 58

Changzhou Extraordinary Pharmatech co., LTD.

Tel: +86-519-82111935 15195055733
Fax: 051982611250
Email: info@feifanchem.com
Country: China
ProdList: 362
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3254
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4399
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 932
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Less

View Lastest Price from Atglistatin manufacturers

Career Henan Chemical Co

Product: Atglistatin 1469924-27-3
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

1469924-27-3, AtglistatinRelated Search:

Geldanamycin ZM 336372 (+)-Camptothecin AAL-993 IKK 16 Y27632 (hydrochloride) Alectinib Masitinib Lenalidomide IPI 145

Atglistatin

Atglistatin, >=98%

3-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea

Atglistatin N'-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylurea

N'-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylurea Atglistatin

3-(4'-(DIMETHYLAMINO)BIPHENYL-3-YL)-1,1-DIMETHYLUREA

N'-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylurea

CS-1024

istatin

Urea, N'-[4'-(dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethyl-

3-(4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)-1,1-dimethylurea

3-[4’-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea

At listatin

Atglistatin, 10 mM in DMSO

1469924-27-3

Inhibitors