CGP 71683 HYDROCHLORIDE
- Product Name
- CGP 71683 HYDROCHLORIDE
- CAS No.
- 192322-50-2
- Chemical Name
- CGP 71683 HYDROCHLORIDE
- Synonyms
- CGP 71683;CGP71683HCl;CGP-71683A HCl;UNII-45B73P82A3;CGP 71683 HYDROCHLORIDE;CGP 71683A hydrochloride;CGP71683 hydrochloride, 10 mM in DMSO;CGP-71683A; CGP 71683A; CGP71683A; UNII-45B73P82A3;N-[[TRANS-4-[[(4-AMINO-2-QUINAZOLINYL)AMINO]METHYL]CYCLOHEXYL]METHYL]-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-rel-(((1r,4r)-4-(((4-Aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride
- CBNumber
- CB8269070
- Molecular Formula
- C26H30ClN5O2S
- Formula Weight
- 512.07
- MOL File
- 192322-50-2.mol
CGP 71683 HYDROCHLORIDE Property
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: ~14 mg/mL, soluble
- form
- solid
- color
- off-white
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28778
- Product name
- CGP 71683 (hydrochloride)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 28778
- Product name
- CGP 71683 (hydrochloride)
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 28778
- Product name
- CGP 71683 (hydrochloride)
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 2199
- Product name
- CGP71683hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $223
- Updated
- 2021/12/16
- Product number
- 2199
- Product name
- CGP71683hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $934
- Updated
- 2021/12/16
CGP 71683 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.
Uses
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
Biological Activity
Extremely selective, non-peptide NPY Y 5 receptor antagonist. Displays > 1000-fold selectivity over Y 1 , Y 2 and Y 4 receptors; IC 50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y 5 , Y 1 , Y 2 and Y 4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.
in vivo
CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats[2].
IC 50
NPY Y5 receptor
storage
Store at +4°C
References
[1] Lecklin A, et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37. DOI:10.1038/sj.bjp.0704667
[2] Costa-e-Sousa RH, et al. Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat. Regul Pept. 2011 Nov 10;171(1-3):43-7. DOI:10.1016/j.regpep.2011.07.001
CGP 71683 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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