CGP 71683 HYDROCHLORIDE
- Product Name
- CGP 71683 HYDROCHLORIDE
- CAS No.
- 192322-50-2
- Chemical Name
- CGP 71683 HYDROCHLORIDE
- Synonyms
- CGP 71683;CGP71683HCl;CGP-71683A HCl;UNII-45B73P82A3;CGP 71683 HYDROCHLORIDE;CGP 71683A hydrochloride;CGP-71683A; CGP 71683A; CGP71683A; UNII-45B73P82A3;N-[[TRANS-4-[[(4-AMINO-2-QUINAZOLINYL)AMINO]METHYL]CYCLOHEXYL]METHYL]-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-rel-(((1r,4r)-4-(((4-Aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride;1-Naphthalenesulfonamide, N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-, hydrochloride (1:1)
- CBNumber
- CB8269070
- Molecular Formula
- C26H30ClN5O2S
- Formula Weight
- 512.07
- MOL File
- 192322-50-2.mol
CGP 71683 HYDROCHLORIDE Property
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: ~14 mg/mL, soluble
- form
- solid
- color
- off-white
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28778
- Product name
- CGP 71683 (hydrochloride)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 28778
- Product name
- CGP 71683 (hydrochloride)
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 28778
- Product name
- CGP 71683 (hydrochloride)
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 2199
- Product name
- CGP71683hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $223
- Updated
- 2021/12/16
- Product number
- 2199
- Product name
- CGP71683hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $934
- Updated
- 2021/12/16
CGP 71683 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.
Biological Activity
Extremely selective, non-peptide NPY Y 5 receptor antagonist. Displays > 1000-fold selectivity over Y 1 , Y 2 and Y 4 receptors; IC 50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y 5 , Y 1 , Y 2 and Y 4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.
storage
Store at +4°C
CGP 71683 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 71683 HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91