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CGP 71683 HYDROCHLORIDE

Product Name
CGP 71683 HYDROCHLORIDE
CAS No.
192322-50-2
Chemical Name
CGP 71683 HYDROCHLORIDE
Synonyms
CGP 71683;CGP71683HCl;CGP-71683A HCl;UNII-45B73P82A3;CGP 71683 HYDROCHLORIDE;CGP 71683A hydrochloride;CGP-71683A; CGP 71683A; CGP71683A; UNII-45B73P82A3;N-[[TRANS-4-[[(4-AMINO-2-QUINAZOLINYL)AMINO]METHYL]CYCLOHEXYL]METHYL]-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-rel-(((1r,4r)-4-(((4-Aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride;1-Naphthalenesulfonamide, N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-, hydrochloride (1:1)
CBNumber
CB8269070
Molecular Formula
C26H30ClN5O2S
Formula Weight
512.07
MOL File
192322-50-2.mol
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CGP 71683 HYDROCHLORIDE Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: ~14 mg/mL, soluble
form 
solid
color 
off-white
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Safety

Safety Statements 
24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28778
Product name
CGP 71683 (hydrochloride)
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28778
Product name
CGP 71683 (hydrochloride)
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
28778
Product name
CGP 71683 (hydrochloride)
Packaging
5mg
Price
$145
Updated
2024/03/01
Tocris
Product number
2199
Product name
CGP71683hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$223
Updated
2021/12/16
Tocris
Product number
2199
Product name
CGP71683hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$934
Updated
2021/12/16
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CGP 71683 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM. CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.

Biological Activity

Extremely selective, non-peptide NPY Y 5 receptor antagonist. Displays > 1000-fold selectivity over Y 1 , Y 2 and Y 4 receptors; IC 50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y 5 , Y 1 , Y 2 and Y 4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

storage

Store at +4°C

CGP 71683 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 71683 HYDROCHLORIDE Suppliers

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192322-50-2, CGP 71683 HYDROCHLORIDERelated Search:

CGP 71683 HYDROCHLORIDE W-5 HYDROCHLORIDE

  • CGP 71683 HYDROCHLORIDE
  • N-[[TRANS-4-[[(4-AMINO-2-QUINAZOLINYL)AMINO]METHYL]CYCLOHEXYL]METHYL]-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
  • CGP 71683
  • CGP71683HCl
  • 1-Naphthalenesulfonamide, N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-, hydrochloride (1:1)
  • UNII-45B73P82A3
  • CGP-71683A; CGP 71683A; CGP71683A; UNII-45B73P82A3
  • CGP 71683A hydrochloride
  • CGP-71683A HCl
  • N-rel-(((1r,4r)-4-(((4-Aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride
  • NPY receptor,CGP-71683,CGP 71683,Inhibitor,inhibit,CGP71683 hydrochloride,CGP-71683 hydrochloride,CGP71683,Neuropeptide Y Receptor
  • 192322-50-2
  • C26H30ClN5O2S
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Forensic and Veterinary Standards
  • Chromatography
  • Drug Standards
  • Neuropeptide Y (NPY ) receptor