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XL999

Product Name
XL999
CAS No.
705946-27-6
Chemical Name
XL999
Synonyms
XL999;XL999;XL 999;Tyrosine kinase-IN-1;Tyrosine kinase inhibitor 1;XL-999(Tyrosine kinase-IN-1);Tyrosine kinase-IN-1, 10 mM in DMSO;(Z)-5-((1-Ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one;(3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)(4-methyl-1H-imidazol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one;2H-Indol-2-one, 5-[(1-ethyl-4-piperidinyl)amino]-3-[(3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene]-1,3-dihydro-, (3Z)-;Tyrosine kinase IN 1,FGFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,Vascular endothelial growth factor receptor,Fibroblast growth factor receptor,inhibit,PDGFR,Tyrosine kinaseIN1
CBNumber
CB82731166
Molecular Formula
C26H28FN5O
Formula Weight
445.53
MOL File
705946-27-6.mol
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XL999 Property

Density 
1.280±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 62.5 mg/mL (140.28 mM)
pka
11.67±0.20(Predicted)
form 
Solid
color 
Light brown to brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0018466
Product name
Tyrosinekinase-IN-1
Purity
99.47%
Packaging
1mg
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-0018466
Product name
Tyrosinekinase-IN-1
Purity
99.47%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0018466
Product name
Tyrosinekinase-IN-1
Purity
99.47%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0018466
Product name
Tyrosinekinase-IN-1
Purity
99.47%
Packaging
25mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0018466
Product name
Tyrosinekinase-IN-1
Purity
99.47%
Packaging
50mg
Price
$450
Updated
2021/12/16
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XL999 Chemical Properties,Usage,Production

Uses

XL999 is a multi-target tyrosine kinase inhibitor. XL999 has IC50 values for KDR, Flt-1, FGFR1 and PDGFRα of 4 nM, 20 nM, 4 nM and 2 nM, respectively. XL999 can be used in the research of cancer[1].

in vivo

XL 999 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats[1].

IC 50

Flt-1: 4 nM (IC50); KDR: 20 nM (IC50); PDGFRα: 4 nM (IC50); FGFR1: 2 nM (IC50)

References

[1] Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985

XL999 Preparation Products And Raw materials

Raw materials

Preparation Products

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XL999 Suppliers

China 35 United States 5 Global 40
Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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sales@shjiyipharmatech.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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8000
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Shenzhen Regent Biochemical Technology Co., Ltd.
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0755-85201366 18938635012
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0755-85201366
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sales@regentsciences.com
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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0371-86658258
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laboratory@coreychem.com
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010-60605840 15801484223;
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705946-27-6, XL999Related Search:

TYRPHOSTIN AG 528 TYRPHOSTIN AG 1296 TYRPHOSTIN A1 AG 18 Tyrphostin AG1433 4-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)phenol 4-HYDROXYBENZYLIDENEMALONONITRILE TYRPHOSTIN A25

  • XL999
  • Tyrosine kinase-IN-1
  • Tyrosine kinase inhibitor 1
  • XL999;XL 999
  • 2H-Indol-2-one, 5-[(1-ethyl-4-piperidinyl)amino]-3-[(3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene]-1,3-dihydro-, (3Z)-
  • Tyrosine kinase IN 1,FGFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,Vascular endothelial growth factor receptor,Fibroblast growth factor receptor,inhibit,PDGFR,Tyrosine kinaseIN1
  • XL-999(Tyrosine kinase-IN-1)
  • (Z)-5-((1-Ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one
  • (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)(4-methyl-1H-imidazol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one
  • Tyrosine kinase-IN-1, 10 mM in DMSO
  • 705946-27-6