Biological Activity
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Atezolizumab

Biological Activity
Product Name
Atezolizumab
CAS No.
1380723-44-3
Chemical Name
Atezolizumab
Synonyms
MPDL3280A;Atezolizumab;Atezolizumab (anti-PD-L1);Research Grade Atezolizumab(DHJ70101);Atezolizumab,Inhibitor,MPDL3280A,inhibit,Apoptosis,Autophagy
CBNumber
CB82744221
Formula Weight
0
MOL File
Mol file
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Atezolizumab Property

storage temp. 
Store at -80°C
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7490
Product name
Atezolizumab
Purity
98.98%
Packaging
1mg
Price
$280
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ATB0023621
Product name
ATEZOLIZUMAB
Purity
95.00%
Packaging
5MG
Price
$450.15
Updated
2021/12/16
Biosynth Carbosynth
Product number
BA165584
Product name
Atezolizumab
Packaging
1mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-7490
Product name
Atezolizumab
Purity
98.98%
Packaging
5mg
Price
$670
Updated
2021/12/16
ChemScene
Product number
CS-7490
Product name
Atezolizumab
Purity
98.98%
Packaging
25mg
Price
$2550
Updated
2021/12/16
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Atezolizumab Chemical Properties,Usage,Production

Biological Activity

Atezolizumab inhibits proliferation and induces immune independent apoptosis of osteosarcoma cells. The proliferation of HOS and 143B both were inhibited by atezolizumab in a dose-dependent manner. The IC50 values of HOS and 143B were between 10-20 μg/ml. Atezolizumab treatment reduces endotoxin levels and intestinal mucosal permeability as well as decreases ileum histological scores in septic mice. However, atezolizumab treatment increases the expression of tight junction proteins in the ileum during sepsis.

Description

Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

Uses

Atezolizumab is an FDA-approved targeted therapy drug. It is a monoclonal antibody that works by binding to PD-L1, a protein on the surface of certain cancer cells, thus preventing the cancer cells from suppressing the immune system. This allows the immune system to attack and kill the cancer cells. Atezolizumab is approved for use alone or with other drugs to treat Alveolar soft part sarcoma, Hepatocellular carcinoma, Melanoma, Non-small cell lung cancer and Small cell lung cancer.

Atezolizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Atezolizumab Suppliers

1380723-44-3, AtezolizumabRelated Search:


  • Atezolizumab
  • MPDL3280A
  • Atezolizumab (anti-PD-L1)
  • Research Grade Atezolizumab(DHJ70101)
  • Atezolizumab,Inhibitor,MPDL3280A,inhibit,Apoptosis,Autophagy
  • 1380723-44-3
  • 380723-44-3