2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
- Product Name
- 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
- CAS No.
- 304684-77-3
- Chemical Name
- 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
- Synonyms
- Exo2;Exo2 >=98% (HPLC);2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol;Benzaldehyde, 4-hydroxy-3-methoxy-, 2-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone
- CBNumber
- CB82750352
- Molecular Formula
- C18H18N4O2S
- Formula Weight
- 354.43
- MOL File
- 304684-77-3.mol
2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Property
- Boiling point:
- 591.0±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- pka
- 8.79±0.35(Predicted)
- color
- yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- E7159
- Product name
- Exo2
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- E7159
- Product name
- Exo2
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $335
- Updated
- 2024/03/01
- Product number
- orb545927
- Product name
- Exo2
- Purity
- >98%
- Packaging
- 5mg
- Price
- $176.8
- Updated
- 2021/12/16
- Product number
- orb545927
- Product name
- Exo2
- Purity
- >98%
- Packaging
- 25mg
- Price
- $469.2
- Updated
- 2021/12/16
- Product number
- PRB0000014
- Product name
- EXO2
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $649.35
- Updated
- 2021/12/16
2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Chemical Properties,Usage,Production
Description
Exo2 (304684-77-3) disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells.1 May be used to completely ablate the Golgi apparatus.1 Like brefeldin A (BFA), it inhibits anterograde transport and disrupts morphology of the trans-Golgi network (TGN) but unlike BFA, it does not induce tubulation and merging of the TGN and endosomal compartments.2? It perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network, in contrast to cholera toxin.1,2 Accelerates degradation of perilipin-2 proteins.3
Definition
ChEBI: Exo2 is a member of phenols and a member of methoxybenzenes.
References
1) Feng et al. (2004), Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells; EMBO Rep., 5 596 2) Spooner et al. (2008), The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network; Biochem. J., 414 471 3) Pauloin et al. (2016), The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in the HC11 mouse mammary epithelial cells; Cell Biol. Int., 40 143
2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Suppliers
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