ChemicalBook > CAS DataBase List > Trifluoromethanesulfonic acid difluoromethyl ester

Trifluoromethanesulfonic acid difluoromethyl ester

Product Name: Trifluoromethanesulfonic acid difluoromethyl ester
CAS No.: 1885-46-7
Chemical Name: Trifluoromethanesulfonic acid difluoromethyl ester
Synonyms: Difluoromethyl triflate;Difluoromethyl triflate 95%;Difluoromethyl trifluoromethanesulfonate;Difluoromethyl trifluoromethanesulfonate 95%;Trifluoromethanesulfonic acid difluoromethyl ester;Methanesulfonic acid, 1,1,1-trifluoro-, difluoromethyl ester
CBNumber: CB82755645
Molecular Formula: C2HF5O3S
Formula Weight: 200.08
MOL File: 1885-46-7.mol

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Trifluoromethanesulfonic acid difluoromethyl ester Property

Boiling point:: 48.5-49 °C
Density: 1.584 g/mL at 25 °C
Flash point:: 57℃
storage temp.: 2-8°C
form: liquid
color: Clear, colourless
InChI: InChI=1S/C2HF5O3S/c3-1(4)10-11(8,9)2(5,6)7/h1H
InChIKey: DAANAKGWBDWGBQ-UHFFFAOYSA-N
SMILES: C(F)(F)(F)S(OC(F)F)(=O)=O

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Safety

Hazard Codes: C,Xn
Risk Statements: 22-34
Safety Statements: 26-36/37/39-45
RIDADR: UN 2920 3(8) / PGII
WGK Germany: 3
HS Code: 2905190098

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 792764
Product name: Difluoromethyl triflate
Purity: 95%
Packaging: 1ml
Price: $148.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 792764
Product name: Difluoromethyl triflate
Purity: 95%
Packaging: 5ml
Price: $331
Updated: 2025/07/31

TRC

Product number: D610240
Product name: Difluoromethyltrifluoromethanesulfonate
Packaging: 1g
Price: $220
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6164-3-45
Product name: Difluoromethyl trifluoromethanesulfonate
Packaging: 5G
Price: $225
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6164-3-45
Product name: Difluoromethyl trifluoromethanesulfonate
Packaging: 1g
Price: $75
Updated: 2021/12/16

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Trifluoromethanesulfonic acid difluoromethyl ester Chemical Properties,Usage,Production

Uses

Difluoromethyl triflate (TfO-CHF₂) can be used as a reagent:

In difluoromethylation reaction.
To prepare difluoromethoxylated heterocycles by reacting with hydroxylated N-based heterocycles.
To synthesize trifluoromethylated arenes by treating with diaryliodonium salts in the presence of copper and tetrabutylammonium difluorotriphenylsilicate (TBAT).

It allows for a simple method toward the preparation of difluoromethyl ethers and thioethers under basic conditions from alcohols and thiols. Difluoromethyl phenols can also be obtained in a single pot from boronic acids and C-H activation of arenes.

General Description

Difluoromethyl triflate (HCF₂OTf) is an easy to handle, air-stable and non-ozone-depleting liquid reagent for difluoromethylation. It can be prepared by reacting trifluoromethyltrimethylsilane (TMSCF₃) and triflic acid in the presence of titanium tetrachloride (TiCl₄).

Trifluoromethanesulfonic acid difluoromethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Trifluoromethanesulfonic acid difluoromethyl ester manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Trifluoromethanesulfonic acid difluoromethyl ester 1885-46-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Trifluoromethanesulfonic acid difluoromethyl ester 1885-46-7
Price: US $0.10/kg
Min. Order: 0.005kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-15

1885-46-7, Trifluoromethanesulfonic acid difluoromethyl esterRelated Search:

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Difluoromethyl trifluoromethanesulfonate 95%

Trifluoromethanesulfonic acid difluoromethyl ester

Difluoromethyl triflate 95%

Difluoromethyl triflate

Difluoromethyl trifluoromethanesulfonate

Methanesulfonic acid, 1,1,1-trifluoro-, difluoromethyl ester

1885-46-7

C2HF5O3S