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PROTOPINE HYDROCHLORIDE

Product Name
PROTOPINE HYDROCHLORIDE
CAS No.
6164-47-2
Chemical Name
PROTOPINE HYDROCHLORIDE
Synonyms
Nsc11440;FUMARINE;MACLEYINE;PROTOPINE HCL;PROTOHYPERICIN(RG);Argemonine (protopine;FUMARINE HYDROCHLORIDE;PROTOPINE HYDROCHLORIDE;13a-secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)-hydrochloride;7,13A-Secoberbin-13A-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride
CBNumber
CB8276092
Molecular Formula
C20H20ClNO5
Formula Weight
389.83
MOL File
6164-47-2.mol
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PROTOPINE HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
solid
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
1544
WGK Germany 
3
RTECS 
UL2000000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
6164-47-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8489
Product name
Protopine hydrochloride
Purity
≥98%, solid
Packaging
5mg
Price
$454
Updated
2024/03/01
Cayman Chemical
Product number
23366
Product name
Protopine (hydrochloride)
Purity
≥98%
Packaging
500μg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
23366
Product name
Protopine (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$166
Updated
2024/03/01
AK Scientific
Product number
8223AH
Product name
Protopine hydrochloride
Packaging
1mg
Price
$282
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HBL0000189
Product name
PROTOPINE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$910.32
Updated
2021/12/16
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PROTOPINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities. It inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma at a concentration of 100 μM. Protopine inhibits contraction of isolated rat thoracic aorta induced by norepinephrine and is a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes. Protopine inhibits the growth of H. pylori with an MIC50 value of 100 μg/ml. It reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest. Protopine (0.005 mg/kg) increases latency to first seizure in a mouse model induced by pentylenetetrazole .

Uses

Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.

General Description

Protopine is a celandine alkaloid and a bioactive compound associated with the plant families including fumariaceae, berberidaceae?and papaveraceae. It is metabolized by demethylenation in the presence of the cytochrome enzymes cytochrome P450 family 2 subfamily d polypeptide 1 (CYP2D1) and cytochrome P450 family 2 subfamily c polypeptide 11 (CYP2C11).

Biochem/physiol Actions

Protopine possesses anti-parasitic, antimicrobial and anti-inflammatory property. It mediates mitotic arrest by favoring tubulin polymerization. Protopine elicits anti-invasive effects in breast cancer tumor progression.. It also provides protection against oxidative stress-induced cell death.

PROTOPINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTOPINE HYDROCHLORIDE Suppliers

China 32 United States 6 Global 38
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6164-47-2, PROTOPINE HYDROCHLORIDERelated Search:

Berberine hydrochloride OPIUM HUNNEMANINE 2-(2-METHYLPHENYL)ACETOPHENONE 6-METHYL-BENZO[1,3]DIOXOLE-5-CARBALDEHYDE CHEMBRDG-BB 5553033 CHEMBRDG-BB 5532546 2-(1,3-BENZODIOXOL-5-YL)-1-PHENYL-1-ETHANONE, 95%+ CHEMBRDG-BB 5545019 3,4-Methylenedioxyacetophenone PIPERONYL METHYL KETONE 3′,4′-(Methylenedioxy)propiophenone PROTOPINE HYDROCHLORIDE Protopine

  • 13a-secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)-hydrochloride
  • PROTOPINE HCL
  • PROTOPINE HYDROCHLORIDE
  • MACLEYINE
  • FUMARINE
  • FUMARINE HYDROCHLORIDE
  • 7,13A-Secoberbin-13A-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride
  • Argemonine (protopine
  • Bis[1,3]benzodioxolo[4,5-C:5',6'-G]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-, hydrochloride
  • Nsc11440
  • PROTOHYPERICIN(RG)
  • 6164-47-2
  • C20H19NO5HCl
  • Calcium Channel Modulators
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Inhibitors and Activators
  • Ion Channels
  • Voltage-gated Ion Channels
  • Nutrition Research
  • Alkaloids
  • AlkaloidVoltage-gated Ion Channels
  • Biochemicals Found in Plants
  • Calcium Channel Modulators
  • Inhibitors and Activators