2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
- Product Name
- 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
- CAS No.
- 21917-76-0
- Chemical Name
- 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
- Synonyms
- BUTTPARK 43\57-58;2-Methyl-4-cyanothiazole;4-Cyano-2-methyl-1,3-thiazole;2-methylthiazol-4-carbonitrile;2-METHYLTHIAZOLE-4-CARBONITRILE;2-Methyl-4-thiazolecarbonitrile;4-THIAZOLECARBONITRILE, 2-METHYL-;2-Methyl-1,3-thiazole-4-carbonitile;2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
- CBNumber
- CB8277039
- Molecular Formula
- C5H4N2S
- Formula Weight
- 124.16
- MOL File
- 21917-76-0.mol
2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Property
- Melting point:
- 58-61°C
- Boiling point:
- 229.4±13.0℃ (760 Torr)
- Density
- 1.25±0.1 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 92.5±19.8℃
- storage temp.
- 2-8°C
- Appearance
- Light brown to brown Solid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-41
- Safety Statements
- 23-36/37/39-39-26
- RIDADR
- 3276
- Hazard Note
- Irritant
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M336543
- Product name
- 2-Methylthiazole-4-carbonitrile
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- OR29666
- Product name
- 2-Methyl-1,3-thiazole-4-carbonitrile
- Packaging
- 1g
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 7H70-1-6Q
- Product name
- 2-Methyl-1,3-thiazole-4-carbonitrile
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CHM0021265
- Product name
- 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $632.8
- Updated
- 2021/12/16
- Product number
- CHM0021265
- Product name
- 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $676.46
- Updated
- 2021/12/16
2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Chemical Properties,Usage,Production
Definition
ChEBI: 2-Methyl-1,3-thiazole-4-carbonitrile is a member of thiazoles.
Synthesis
31825-95-3
21917-76-0
The general procedure for synthesizing 2-methyl-1,3-thiazole-4-carbonitrile from 2-methylthiazole-4-carboxamide is as follows: general method: after completing the preparation of the amide intermediate, carry out the operation in Example A. According to the relationship between the boiling point of the amide intermediate and the reaction temperature TB, decide the state of the reaction vessel: if the boiling point of the amide intermediate at atmospheric pressure is equal to or lower than TB, close the reaction vessel; if the boiling point is higher than TB, keep the reaction vessel open. The stirring rate was maintained at 600 rpm, the reaction temperature was adjusted to TB and maintained at this temperature for TD hours until the reaction was nearly complete. Subsequently, the reaction vessel was sealed and connected to a vacuum pump, the vacuum in the reaction vessel was adjusted to 20-50 mbar (depending on the nature of the nitrile product) and the distillate was collected as the nitrile product. The yield was calculated and samples were taken for NMR spectroscopy and elemental analysis to characterize the obtained nitrile product. The specific reaction conditions and characterization results are detailed in Tables A-7, A-8, A-9, A-10, and A-11. The characterization results showed that the resulting nitrile product was of very high purity (over 99%). In some embodiments of the preparation of the nitrile product, 10 g of phosphorus pentoxide was selectively added as a catalyst at the initial stage of the reaction.
References
[1] Patent: CN104557357, 2018, B. Location in patent: Paragraph 0150; 0151; 0152; 0162
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 628 - 633
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[4] Patent: WO2011/106414, 2011, A1. Location in patent: Page/Page column 83
[5] Journal of the Chemical Society [Section] C: Organic, 1969, p. 707 - 710
2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Suppliers
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View Lastest Price from 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE manufacturers
- Product
- 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE 21917-76-0
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25