5-BROMO-3-CHLORO-2-METHYLPYRIDINE

Product Name: 5-BROMO-3-CHLORO-2-METHYLPYRIDINE
CAS No.: 914358-72-8
Chemical Name: 5-BROMO-3-CHLORO-2-METHYLPYRIDINE
Synonyms: 5-BroMo-3-chloro-2-Methyl...;5-BROMO-3-CHLORO-2-METHYLPYRIDINE;2-Methyl-3-chloro-5-bromopyridine;Pyridine, 5-bromo-3-chloro-2-methyl-;5-BROMO-3-CHLORO-2-METHYLPYRIDINE ISO 9001：2015 REACH
CBNumber: CB6817501
Molecular Formula: C6H5BrClN
Formula Weight: 206.47
MOL File: 914358-72-8.mol

More

Less

5-BROMO-3-CHLORO-2-METHYLPYRIDINE Property

Boiling point:: 208℃
Density: 1.624
Flash point:: 80℃
storage temp.: Inert atmosphere,Room Temperature
pka: 1.31±0.20(Predicted)
Appearance: White to off-white Solid

More

Less

Safety

RIDADR: UN2811
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B690703
Product name: 5-Bromo-3-chloro-2-methylpyridine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B690703
Product name: 5-Bromo-3-chloro-2-methylpyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55673
Product name: 5-Bromo-3-chloro-2-methylpyridine
Packaging: 500mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55673
Product name: 5-Bromo-3-chloro-2-methylpyridine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: J94851
Product name: 5-Bromo-3-chloro-2-methylpyridine
Packaging: 5g
Price: $120
Updated: 2021/12/16

More

Less

5-BROMO-3-CHLORO-2-METHYLPYRIDINE Chemical Properties,Usage,Production

Uses

5-BROMO-3-CHLORO-2-METHYLPYRIDINE is a heterocyclic compound that belongs to the pyridine family. It is characterized by its unique structure and functional groups, including a bromo and chloro substituent, which make it highly reactive and versatile. It serves as an important intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals, and is also used as a reagent in organic synthesis and medicinal chemistry.

Synthesis

1383985-17-8

914358-72-8

General procedure for the synthesis of 2-methyl-3-chloro-5-bromopyridine from diethyl 2-(5-bromo-3-chloropyridin-2-yl)malonate: firstly, impure diethyl 2-(5-bromo-3-chloropyridin-2-yl)malonate (Intermediate 42, 0.41 g, 1.2 mmol) was dissolved in a concentrated aqueous hydrochloric acid solution (3 mL), and heated and refluxed for 3 hours. Upon completion of the reaction, volatiles were removed by vacuum distillation and the residue was co-evaporated with acetonitrile. Subsequently, the resulting monodeoxycarboxylic acid solid was dissolved in dioxane (4.5 mL) and heated to reflux overnight. The volatiles were again removed by vacuum distillation. Finally, the residue was purified by fast chromatography (using 4 g SiO2, heptane/EtOAc gradient elution) to afford the target product 2-methyl-3-chloro-5-bromopyridine (0.12 g, 51% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 2.60 (s, 3H), 7.82 (d, 1H), 8.46 (d, 1H); the mass spectrum (CI) showed m/z 206 [M + H]+.

References

[1] Patent: US2012/165347, 2012, A1. Location in patent: Page/Page column 32

5-BROMO-3-CHLORO-2-METHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-BROMO-3-CHLORO-2-METHYLPYRIDINE Suppliers

China 72 India 1 United Kingdom 2 United States 13 Global 88

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Nan Jing Dirise Chemcial Co.,LTD

Tel: 025-52161033 15312098939
Fax: 025-83254025
Email: sales@njdrschem.com
Country: China
ProdList: 583
Advantage: 64

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

More

Less

View Lastest Price from 5-BROMO-3-CHLORO-2-METHYLPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-bromo-3-chloro-2-methylpyridine 914358-72-8
Price: US $1.00/KG
Min. Order: 1ASSAYS
Purity: 98%
Supply Ability: 20T
Release date: 2019-12-26

Dideu Industries Group Limited

Product: 5-BROMO-3-CHLORO-2-METHYLPYRIDINE 914358-72-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-3-CHLORO-2-METHYLPYRIDINE 914358-72-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

914358-72-8, 5-BROMO-3-CHLORO-2-METHYLPYRIDINERelated Search:

2-Methyl-3-nitro-5-trifluoroMethyl-pyridine 2-Methyl-1,4-benzenedicarboxylic acid METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE 2-methyl-2-(4-nitrophenyl)propanenitrile 5-BROMO-2-CHLORO-6-METHYLPYRIDINE 5-BROMO-2-CHLORO-3-PICOLINE (5-BROMO-2-CHLORO-3-METHYLPYRIDINE),5-BROMO-2-CHLORO-3-METHYLPYRIDINE,5-Bromo-2-chloro-3-methylpyridine ,98% 2-BROMO-5-CHLORO-3-METHYLPYRIDINE,5-BROMO-2-CHLORO-3-METHYLPYRIDINE 3-BROMO-2-CHLORO-4-METHYLPYRIDINE 5-BROMO-3-CHLORO-2-METHYLPYRIDINE 3-Bromo-2-chloro-5-methylpyridine 97%,3-BROMO-2-CHLORO-5-METHYLPYRIDINE 2-BROMO-3-CHLORO-5-METHYLPYRIDINE 3-BROMO-2-CHLORO-6-METHYLPYRIDINE 2-Bromo-6-chloro-3-methylpyridine 2-BROMO-5-CHLORO-4-METHYLPYRIDINE 3-AMINO-6-BROMO-2-CHLORO-4-METHYLPYRIDINE 4-Bromo-2-chloro-3-methylpyridine 2-Bromo-3-chloro-4-methylpyridine 3-BROMO-2-CHLORO-6-PICOLINE (3-BROMO-2-CHLORO-6-METHYLPYRIDINE)

5-BROMO-3-CHLORO-2-METHYLPYRIDINE

5-BroMo-3-chloro-2-Methyl...

2-Methyl-3-chloro-5-bromopyridine

Pyridine, 5-bromo-3-chloro-2-methyl-

5-BROMO-3-CHLORO-2-METHYLPYRIDINE ISO 9001：2015 REACH

914358-72-8