ChemicalBook > CAS DataBase List > 5-BROMO-3-CHLORO-2-METHYLPYRIDINE
5-BROMO-3-CHLORO-2-METHYLPYRIDINE
- Product Name
- 5-BROMO-3-CHLORO-2-METHYLPYRIDINE
- CAS No.
- 914358-72-8
- Chemical Name
- 5-BROMO-3-CHLORO-2-METHYLPYRIDINE
- Synonyms
- 5-BroMo-3-chloro-2-Methyl...;5-BROMO-3-CHLORO-2-METHYLPYRIDINE;2-Methyl-3-chloro-5-bromopyridine;Pyridine, 5-bromo-3-chloro-2-methyl-;5-BROMO-3-CHLORO-2-METHYLPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB6817501
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 914358-72-8.mol
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5-BROMO-3-CHLORO-2-METHYLPYRIDINE Property
- Boiling point:
- 208℃
- Density
- 1.624
- Flash point:
- 80℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 1.31±0.20(Predicted)
- Appearance
- White to off-white Solid
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Safety
- RIDADR
- UN2811
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B690703
- Product name
- 5-Bromo-3-chloro-2-methylpyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
TRC
- Product number
- B690703
- Product name
- 5-Bromo-3-chloro-2-methylpyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB55673
- Product name
- 5-Bromo-3-chloro-2-methylpyridine
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB55673
- Product name
- 5-Bromo-3-chloro-2-methylpyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
AK Scientific
- Product number
- J94851
- Product name
- 5-Bromo-3-chloro-2-methylpyridine
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
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5-BROMO-3-CHLORO-2-METHYLPYRIDINE Chemical Properties,Usage,Production
Uses
5-BROMO-3-CHLORO-2-METHYLPYRIDINE is a heterocyclic compound that belongs to the pyridine family. It is characterized by its unique structure and functional groups, including a bromo and chloro substituent, which make it highly reactive and versatile. It serves as an important intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals, and is also used as a reagent in organic synthesis and medicinal chemistry.
Synthesis
1383985-17-8
914358-72-8
General procedure for the synthesis of 2-methyl-3-chloro-5-bromopyridine from diethyl 2-(5-bromo-3-chloropyridin-2-yl)malonate: firstly, impure diethyl 2-(5-bromo-3-chloropyridin-2-yl)malonate (Intermediate 42, 0.41 g, 1.2 mmol) was dissolved in a concentrated aqueous hydrochloric acid solution (3 mL), and heated and refluxed for 3 hours. Upon completion of the reaction, volatiles were removed by vacuum distillation and the residue was co-evaporated with acetonitrile. Subsequently, the resulting monodeoxycarboxylic acid solid was dissolved in dioxane (4.5 mL) and heated to reflux overnight. The volatiles were again removed by vacuum distillation. Finally, the residue was purified by fast chromatography (using 4 g SiO2, heptane/EtOAc gradient elution) to afford the target product 2-methyl-3-chloro-5-bromopyridine (0.12 g, 51% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 2.60 (s, 3H), 7.82 (d, 1H), 8.46 (d, 1H); the mass spectrum (CI) showed m/z 206 [M + H]+.
References
[1] Patent: US2012/165347, 2012, A1. Location in patent: Page/Page column 32
5-BROMO-3-CHLORO-2-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-3-CHLORO-2-METHYLPYRIDINE manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 5-bromo-3-chloro-2-methylpyridine 914358-72-8
- Price
- US $1.00/KG
- Min. Order
- 1ASSAYS
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2019-12-26
Dideu Industries Group Limited
- Product
- 5-BROMO-3-CHLORO-2-METHYLPYRIDINE 914358-72-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 5-BROMO-3-CHLORO-2-METHYLPYRIDINE 914358-72-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
914358-72-8, 5-BROMO-3-CHLORO-2-METHYLPYRIDINERelated Search:
2-Methyl-3-nitro-5-trifluoroMethyl-pyridine
2-Methyl-1,4-benzenedicarboxylic acid
METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE
2-methyl-2-(4-nitrophenyl)propanenitrile
5-BROMO-2-CHLORO-6-METHYLPYRIDINE
5-BROMO-2-CHLORO-3-PICOLINE (5-BROMO-2-CHLORO-3-METHYLPYRIDINE),5-BROMO-2-CHLORO-3-METHYLPYRIDINE,5-Bromo-2-chloro-3-methylpyridine ,98%
2-BROMO-5-CHLORO-3-METHYLPYRIDINE,5-BROMO-2-CHLORO-3-METHYLPYRIDINE
3-BROMO-2-CHLORO-4-METHYLPYRIDINE
5-BROMO-3-CHLORO-2-METHYLPYRIDINE
3-Bromo-2-chloro-5-methylpyridine 97%,3-BROMO-2-CHLORO-5-METHYLPYRIDINE
2-BROMO-3-CHLORO-5-METHYLPYRIDINE
3-BROMO-2-CHLORO-6-METHYLPYRIDINE
2-Bromo-6-chloro-3-methylpyridine
2-BROMO-5-CHLORO-4-METHYLPYRIDINE
3-AMINO-6-BROMO-2-CHLORO-4-METHYLPYRIDINE
4-Bromo-2-chloro-3-methylpyridine
2-Bromo-3-chloro-4-methylpyridine
3-BROMO-2-CHLORO-6-PICOLINE (3-BROMO-2-CHLORO-6-METHYLPYRIDINE)