2-METHYL-1,3-THIAZOLE-4-CARBONITRILE

Product Name: 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
CAS No.: 21917-76-0
Chemical Name: 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
Synonyms: BUTTPARK 43\57-58;2-Methyl-4-cyanothiazole;4-Cyano-2-methyl-1,3-thiazole;2-methylthiazol-4-carbonitrile;2-METHYLTHIAZOLE-4-CARBONITRILE;2-Methyl-4-thiazolecarbonitrile;4-THIAZOLECARBONITRILE, 2-METHYL-;2-Methyl-1,3-thiazole-4-carbonitile;2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
CBNumber: CB8277039
Molecular Formula: C5H4N2S
Formula Weight: 124.16
MOL File: 21917-76-0.mol

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2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Property

Melting point:: 58-61°C
Boiling point:: 229.4±13.0℃ (760 Torr)
Density: 1.25±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:: 92.5±19.8℃
storage temp.: 2-8°C
Appearance: Light brown to brown Solid

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-41
Safety Statements: 23-36/37/39-39-26
RIDADR: 3276
Hazard Note: Irritant
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: M336543
Product name: 2-Methylthiazole-4-carbonitrile
Packaging: 1g
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: OR29666
Product name: 2-Methyl-1,3-thiazole-4-carbonitrile
Packaging: 1g
Price: $86
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-1-6Q
Product name: 2-Methyl-1,3-thiazole-4-carbonitrile
Packaging: 1g
Price: $95
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021265
Product name: 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
Purity: 95.00%
Packaging: 250MG
Price: $632.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021265
Product name: 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE
Purity: 95.00%
Packaging: 1G
Price: $676.46
Updated: 2021/12/16

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2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Chemical Properties,Usage,Production

Definition

ChEBI: 2-Methyl-1,3-thiazole-4-carbonitrile is a member of thiazoles.

Synthesis

31825-95-3

21917-76-0

The general procedure for synthesizing 2-methyl-1,3-thiazole-4-carbonitrile from 2-methylthiazole-4-carboxamide is as follows: general method: after completing the preparation of the amide intermediate, carry out the operation in Example A. According to the relationship between the boiling point of the amide intermediate and the reaction temperature TB, decide the state of the reaction vessel: if the boiling point of the amide intermediate at atmospheric pressure is equal to or lower than TB, close the reaction vessel; if the boiling point is higher than TB, keep the reaction vessel open. The stirring rate was maintained at 600 rpm, the reaction temperature was adjusted to TB and maintained at this temperature for TD hours until the reaction was nearly complete. Subsequently, the reaction vessel was sealed and connected to a vacuum pump, the vacuum in the reaction vessel was adjusted to 20-50 mbar (depending on the nature of the nitrile product) and the distillate was collected as the nitrile product. The yield was calculated and samples were taken for NMR spectroscopy and elemental analysis to characterize the obtained nitrile product. The specific reaction conditions and characterization results are detailed in Tables A-7, A-8, A-9, A-10, and A-11. The characterization results showed that the resulting nitrile product was of very high purity (over 99%). In some embodiments of the preparation of the nitrile product, 10 g of phosphorus pentoxide was selectively added as a catalyst at the initial stage of the reaction.

References

[1] Patent: CN104557357, 2018, B. Location in patent: Paragraph 0150; 0151; 0152; 0162
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 628 - 633
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[4] Patent: WO2011/106414, 2011, A1. Location in patent: Page/Page column 83
[5] Journal of the Chemical Society [Section] C: Organic, 1969, p. 707 - 710

2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYL-1,3-THIAZOLE-4-CARBONITRILE Suppliers

Belgium 1 China 49 Germany 2 India 2 United Kingdom 5 United States 13 Global 72

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View Lastest Price from 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE manufacturers

Career Henan Chemical Co

Product: 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE 21917-76-0
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

21917-76-0, 2-METHYL-1,3-THIAZOLE-4-CARBONITRILERelated Search:

2-METHYL-1H-PYRROLO[2,3-C]PYRIDINE 5-BROMO-3-CHLORO-2-METHYLPYRIDINE 2-METHYL-3-PHENYLPYRIDINE Dimethyl 2-methylterephthalate 2-Methyl-1,3-thiazole-4-carboxylic acid 2-Methyl-3-nitro-5-trifluoroMethyl-pyridine 2-Methyl-1,4-benzenedicarboxylic acid METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE 2-methyl-2-(4-nitrophenyl)propanenitrile Benzothiazole-2-acetonitrile 5-bromo-2-methyl-1,3-thiazole-4-carbonitrile 4-CYANOTHIAZOLE 2-(1H-IMIDAZOL-2-YL)-THIAZOLE-4-CARBONITRILE 2-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]-1,3-THIAZOLE-4-CARBONITRILE 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE

4-THIAZOLECARBONITRILE, 2-METHYL-

2-METHYL-1,3-THIAZOLE-4-CARBONITRILE

2-METHYLTHIAZOLE-4-CARBONITRILE

BUTTPARK 43\57-58

2-Methyl-1,3-thiazole-4-carbonitile

2-Methyl-4-cyanothiazole

4-Cyano-2-methyl-1,3-thiazole

2-Methyl-4-thiazolecarbonitrile

2-methylthiazol-4-carbonitrile

21917-76-0