Cyclosporin H

ChemicalBook > CAS DataBase List > Cyclosporin H

Product Name: Cyclosporin H
CAS No.: 83602-39-5
Chemical Name: Cyclosporin H
Synonyms: CS-1030;CS-1741;Sandoz 37-839;CYCLOSPORIN H;CsH cyclosporin;Cyclosporin H, >=95%;Cyclosporin impurity H;Cyclosporine IMpurity-H;Cyclosporine Impurity 8;Cyclosporin H, EvoPure?
CBNumber: CB8279114
Molecular Formula: C62H111N11O12
Formula Weight: 1202.61
MOL File: 83602-39-5.mol

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Cyclosporin H Property

Melting point:: 148-151°C
Boiling point:: 1293.8±65.0 °C(Predicted)
Density: 1.016±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
pka: 13.32±0.70(Predicted)
form: powder
color: white to beige
optical activity: [α]/D -100 to -115°, c = 0.5 in methanol

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Safety

HS Code: 29420000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H350May cause cancer

H360May damage fertility or the unborn child

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1575
Product name: Cyclosporin H
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1575
Product name: Cyclosporin H
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 17182
Product name: Cyclosporin H
Purity: ≥95%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 17182
Product name: Cyclosporin H
Purity: ≥95%
Packaging: 5mg
Price: $385
Updated: 2024/03/01

Tocris

Product number: 6982
Product name: Cyclosporin H
Purity: ≥97%(HPLC)
Packaging: 5
Price: $295
Updated: 2021/12/16

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Cyclosporin H Chemical Properties,Usage,Production

Description

Cyclosporin H is a natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 μM. Unlike cyclosporin A , cyclosporin H does not bind cyclophilin to evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit phorbol ester-mediated effects in mouse skin and block calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

Chemical Properties

White Powder

Uses

An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Uses

Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Uses

Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclopsorin H is the most extensively investigated of the minor cyclosporin analogues and displays a range of activities. It is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.

Biochem/physiol Actions

Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils. Cyclosporin H does not bind cyclophilin or evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit tumor promoting phorbol ester TPA/PMA in mouse skin cells and to inhibit calcium/calmodulin-dependent EF-2 phosphorylation.

storage

+4°C

References

[1]. wenzel-seifert k, seifert r. cyclosporin h is a potent and selective formyl peptide receptor antagonist. comparison with n-t-butoxycarbonyl-l-phenylalanyl-l-leucyl-l-phenylalanyl-l- leucyl-l-phenylalanine and cyclosporins a, b, c, d, and e. j immunol, 1993, 150(10): 4591-4599.
[2]. wenzel-seifert k, grünbaum l, seifert r. differential inhibition of human neutrophil activation by cyclosporins a, d, and h. cyclosporin h is a potent and effective inhibitor of formyl peptide-induced superoxide formation. j immunol, 1991, 147(6): 1940-1946.
[3]. de paulis a, ciccarelli a, de crescenzo g, et al. cyclosporin h is a potent and selective competitive antagonist of human basophil activation by n-formyl-methionyl-leucyl-phenylalanine. j allergy clin immunol, 1996, 98(1): 152-164.
[4]. kitagaki k, nagai h, hayashi s, et al. facilitation of apoptosis by cyclosporins a and h, but not fk506 in mouse bronchial eosinophils. eur j pharmacol, 1997, 337(2-3): 283-289.

Cyclosporin H Preparation Products And Raw materials

Raw materials

Preparation Products

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83602-39-5, Cyclosporin HRelated Search:

Kresoxim-methyl Triphyl valsartan Methylparaben Tosylmethyl isocyanide Phenylmethylsulfonyl fluoride Cyclosporin A Cyclopentane Hexamethylphosphoramide Tribenuron methyl Methyl acrylate Methyl salicylate Methanol CYCLOSPORIN D CYCLOSPORIN C Methyl Cyclosporin A / B / C / D / H A 59865-13-3 /,CYCLOSPORIN cyclosporin G Cyclosporin D-d4

CYCLOSPORIN H

Cyclosporin H/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]

CS-1741

CS-1030

Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]

5-(N-Methyl-D-valine)cyclosporin A

Cyclo[L-alanyl-D-alanyl-N-Methyl-L- leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl]

Sandoz 37-839

Cyclosporin H, >=95%

Cyclosporin H, 95%, from Micromonospora

Cyclosporin Impurity 8(Cyclosporin H)

Cyclosporine IMpurity-H

5-(N-Methyl-D-valine)cyclosporine A

Cyclosporin H, froM MicroMonospora

Cyclosporin A, 5-(N-methyl-D-valine)-

Cyclosporine Impurity 8

(3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

Cyclosporin Impurity HQ: What is Cyclosporin Impurity H Q: What is the CAS Number of Cyclosporin Impurity H Q: What is the storage condition of Cyclosporin Impurity H Q: What are the applications of Cyclosporin Impurity H

Cyclosporin impurity H

Cyclosporin H, EvoPure?

CsH cyclosporin

(3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone

Cyclosporin H, TPA/PMA inhibitor

83602-39-5

C62H111N11O12

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