1-(1-bromoethyl)-4-fluorobenzene

Product Name: 1-(1-bromoethyl)-4-fluorobenzene
CAS No.: 65130-46-3
Chemical Name: 1-(1-bromoethyl)-4-fluorobenzene
Synonyms: 1-(1-Bromoethyl);-4-fluorobenzene;4-FLUOROPHENETHYL BROMIDE;2-(4-FLUOROPHENYL)ETHYL BROMIDE;1-(4-Fluorophenyl)ethyl bromide;1-(1-Bromoethyl)-4-fluorobenzene;1-BROMO-2-(4-FLUOROPHENYL)ETHANE;1-FLUORO-4-(2-BROMOETHYL)BENZENE;4-FLUORO-1-(2-BROMOETHYL)BENZENE;1-Bromo-1-(4-fluorophenyl)ethane
CBNumber: CB8280260
Molecular Formula: C8H8BrF
Formula Weight: 203.05
MOL File: 65130-46-3.mol

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1-(1-bromoethyl)-4-fluorobenzene Property

Boiling point:: 100-104 °C15 mm Hg(lit.)
Density: 1.4498 g/mL at 25 °C(lit.)
refractive index: n20/D 1.534(lit.)
Flash point:: 200 °F
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: oil
color: Colourless

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-51/53
Safety Statements: 61
WGK Germany: 2
Hazard Note: Harmful
HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B997355
Product name: 1-(1-Bromoethyl)-4-fluorobenzene
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 1700-B-95
Product name: 1-Bromo-1-(4-fluorophenyl)ethane
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 1700-B-95
Product name: 1-Bromo-1-(4-fluorophenyl)ethane
Purity: 98%
Packaging: 5G
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB102294
Product name: 1-(1-Bromoethyl)-4-fluorobenzene
Packaging: 500mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB102294
Product name: 1-(1-Bromoethyl)-4-fluorobenzene
Packaging: 1g
Price: $80
Updated: 2021/12/16

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1-(1-bromoethyl)-4-fluorobenzene Chemical Properties,Usage,Production

Synthesis

403-41-8

65130-46-3

General procedure for the synthesis of 1-(1-bromoethyl)-4-fluorobenzene from 1-(4-fluorophenyl)-1-ethanol: 1-(4-fluorophenyl)ethanol (0.455 mL, 3.57 mmol) was mixed with phosphorus tribromide (0.673 mL, 7.13 mmol) in chloroform (10 mL) and heated to a temperature of 70°C for 3 days. Upon completion of the reaction, the reaction mixture was quenched by pouring it into ice water and diluted with ethyl acetate. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuum to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/dichloromethane (2:1) as eluent to afford 1-(1-bromoethyl)-4-fluorobenzene (154 mg, 0.758 mmol, 21.3% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 7.49-7.40 (m, 2H), 7.09-7.00 (m , 2H), 5.23 (q, J = 7.0 Hz, 1H), 2.06 (d, J = 6.8 Hz, 3H).

References

[1] Journal of the American Chemical Society, 2016, vol. 138, # 34, p. 10774 - 10777
[2] Patent: US2012/46301, 2012, A1. Location in patent: Page/Page column 30; 31
[3] Patent: WO2018/148626, 2018, A1. Location in patent: Page/Page column 152
[4] Tetrahedron, 1977, vol. 33, p. 1581 - 1585
[5] Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1984, vol. 23, # 1, p. 60 - 62

1-(1-bromoethyl)-4-fluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-bromoethyl)-4-fluorobenzene Suppliers

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65130-46-3, 1-(1-bromoethyl)-4-fluorobenzeneRelated Search:

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