PPACK, DIHYDROCHLORIDE
- Product Name
- PPACK, DIHYDROCHLORIDE
- CAS No.
- 142036-63-3
- Chemical Name
- PPACK, DIHYDROCHLORIDE
- Synonyms
- PPACK, DiHCl;D-Phe-Pro-Arg-CMK.HCl;PPACK TRIFLUOROACETATE;PPACK, DIHYDROCHLORIDE;H-D-PHE-PRO-ARG-CMK 2HCL;PPACK, DIHYDROCHLORIDE USP/EP/BP;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL;PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL]
- CBNumber
- CB8280442
- Molecular Formula
- C21H32Cl2N6O3
- Formula Weight
- 487.43
- MOL File
- 142036-63-3.mol
PPACK, DIHYDROCHLORIDE Property
- storage temp.
- 0-6°C
- solubility
- ≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O
N-Bromosuccinimide Price
- Product number
- 520222
- Product name
- PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
- Packaging
- 5mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 520222
- Product name
- PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem
- Packaging
- 25mg
- Price
- $964
- Updated
- 2024/03/01
- Product number
- P5504-80
- Product name
- PPACK Dihydrochloride
- Packaging
- 5mg
- Price
- $409
- Updated
- 2021/12/16
- Product number
- A2588
- Product name
- PPACKDihydrochloride
- Packaging
- 5mg
- Price
- $263
- Updated
- 2021/12/16
PPACK, DIHYDROCHLORIDE Chemical Properties,Usage,Production
Biological Activity
ppack dihydrochloride is the dihydrochloride form of its active component ppack (d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant kivalue of 0.24 nm. ppack covalently binds to the specific active-site ser of thrombin and cross links with his57 at the binding site forming a tetrahedral ppack-thrombin complex. the complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. ppack is currently being investigated as an anti-coagulant to prevent blood coagulation. study results show that ppack is able to dose-dependently inhibit thrombin-induced platelet accumulation.jun t. liu, william paul, michael emerson, carla cicala and clive p. page. thrombin inhibitors and anti-coagulants on thrombin-induced embolization in rabbit cranial vasculature. european journal of pharmacology 264 (1994) 183-190ildiko m. kovach, paul kelley, carol eddy, frank jordan and ahmet baykal. proton bridging in the interactions of thrombin with small inhibitors. biochemistry. 2009; 48(30): 7296-7304martha e. lyon, james s. fine, paul j. henderson and andrew w. lyon. d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone (ppack): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. clin. chem. 41/7, 1038-1041 (1995)
PPACK, DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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