ChemicalBook > CAS DataBase List > D-Luciferin

D-Luciferin

Product Name
D-Luciferin
CAS No.
2591-17-5
Chemical Name
D-Luciferin
Synonyms
uciferin;LUCIFERIN;D-LUCIFERIN;D-Leciferin;LUCIFERIN, D-;D(-)-LUCIFERIN;AURORA KA-6717;BEETLE LUCIFERIN;FIREFLY LUCIFERIN;Photinus luciferin
CBNumber
CB8283216
Molecular Formula
C11H8N2O3S2
Formula Weight
280.32
MOL File
2591-17-5.mol
More
Less

D-Luciferin Property

Melting point:
200-204 °C
alpha 
D22 -36° (c = 1.2 in DMF)
Boiling point:
587.6±60.0 °C(Predicted)
Density 
1.4916 (rough estimate)
refractive index 
1.5650 (estimate)
storage temp. 
-20°C
solubility 
DMF:30.0(Max Conc. mg/mL);107.02(Max Conc. mM)
DMSO:35.33(Max Conc. mg/mL);126.05(Max Conc. mM)
pka
8.31±0.40(Predicted)
form 
Powder
color 
Off-white to light yellow
λmax
360nm(H2O)(lit.)
Merck 
14,4086
BRN 
30484
InChI
InChI=1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1
InChIKey
BJGNCJDXODQBOB-SSDOTTSWSA-N
SMILES
S1C[C@H](C(O)=O)N=C1C1=NC2=CC=C(O)C=C2S1
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-24/25
WGK Germany 
3
F 
8-10
HS Code 
29342000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6152
Product name
D-Luciferin
Purity
synthetic, BioXtra, ≥99% (HPLC)
Packaging
1mg
Price
$279
Updated
2024/03/01
Sigma-Aldrich
Product number
L6152
Product name
D-Luciferin
Purity
synthetic, BioXtra, ≥99% (HPLC)
Packaging
10mg
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
A5030
Product name
D-(-)-Luciferin [Chemiluminescence Reagent]
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$204
Updated
2024/03/01
TCI Chemical
Product number
A5030
Product name
D-(-)-Luciferin [Chemiluminescence Reagent]
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$622
Updated
2024/03/01
Cayman Chemical
Product number
25836
Product name
D-Luciferin
Purity
≥98%
Packaging
10mg
Price
$37
Updated
2024/03/01
More
Less

D-Luciferin Chemical Properties,Usage,Production

Description

D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. In an immunocompetent mouse model of ovarian cancer, the use of D-luciferin substrate and firefly luciferase preserves tumour-host immune interactions since bioluminescent imaging is a more sensitive indication of tumour growth than weight gain.

Chemical Properties

off-white to light yellow powder

Uses

D-Luciferin has been used in determining luciferase activity by luciferase assay in mice and Arabidopsis thaliana seeds. It has also been used in measuring bioluminescence in neonatal rat ventricular cardiomyocytes.

Uses

D-Luciferin has been used in the preparation of the reaction mixture for nitric oxide determination by minescence measurement. It has also been used in the preparation of D-luciferin stock solution for luciferin assays.

Uses

In the assay of ATP.

Definition

ChEBI: A 1,3-thiazolemonocarboxylic acid consisting of 3,5-dihydrothiophene-4-carboxylic acid having a 6-hydroxybenzothiazol-2-yl group at the 2-position.

General Description

D-Luciferin is a small molecule present abundantly in bioluminescent organisms. This molecule is sensitive to oxygen and light.

Biochem/physiol Actions

D-Luciferin uptake within the cells is regulated by the adenosine triphosphate (ATP)-binding cassette (ABC) transporter inhibitors like ATP-binding cassette transporter G2 (ABCG2)/ breast cancer resistance protein (BCRP) inhibitor fumitremorgin C. This substrate is oxidized by firefly luciferase that results in emitting a photon, which has the capability of passing through living tissues.

Purification Methods

D-Luciferin crystallises as pale yellow needles from H2O, or MeOH (83mg/7mL). It has UV max at 263 and 327nm (log 3.88 and 4.27) in 95% EtOH. The Na salt has a solubility of 4mg in 1 mL of 0.05M glycine. [White et al. J Am Chem Soc 83 2402 1961, 85 337 1963, UV and IR: Bitler & McElroy Arch Biochem 72 358 1957, Review: Cormier et al. Fortschr Chem Org Naturst 30 1 1973, Beilstein 27 III/IV 8934.]

D-Luciferin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

D-Luciferin Suppliers

Americas 1 Belgium 1 China 229 Estonia 2 Europe 2 France 2 Germany 14 India 10 Japan 1 Poland 1 Russia 1 South Korea 1 Switzerland 4 The Netherlands 1 United Kingdom 18 United States 41 Global 329
Heliosense Biotechnologies,Inc
Tel
0592-5667290 18649641090
Fax
0592-5667261
Email
info@heliosense.com
Country
China
ProdList
98
Advantage
58
Shanghai Better-In Pharmaceutical Technology Co.,Ltd.
Tel
021-38921049 13564871374
Fax
+86-21-38921049
Email
sales@better-in.com
Country
China
ProdList
44
Advantage
55
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1946
Advantage
58
ShenZhen Davoos Tech Ltd
Tel
0752-5555973 13923768523
Email
95372103@qq.com
Country
China
ProdList
670
Advantage
58
Hubei Innerse Biotechnology Co., Ltd.
Tel
027-027-88189299 18186187538
Email
sales@innersebio.com
Country
China
ProdList
104
Advantage
58
Zhangshu Chenxi Biotechnology Co., Ltd
Tel
0791-83064768 19070905030
Email
cx@chenxisw.com
Country
China
ProdList
57
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169097
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Goodee Pharma Co., Ltd.
Tel
0512-62956210
Email
yongyan@goodeepharma.com
Country
China
ProdList
132
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4654
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6181
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
shanghai aokchem co., ltd
Tel
021-68712331 39130253
Fax
18621350903
Email
aokchem@gmail.com
Country
China
ProdList
332
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7876
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8033
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3924
Advantage
50
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
Wuhan Chemduro Pharm Tech Co. Ltd.
Tel
18040571231/1402788087
Fax
sales@chemduro.com
Country
China
ProdList
1973
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2071
Advantage
56
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653713 17501653715
Email
xingui2022@126.com
Country
China
ProdList
10033
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4992
Advantage
55
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
021-54581719 13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1725
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
Beijing NuoqiYa Biotechnology Co., Ltd.
Tel
4000-819-385 010-62329685 13718666987
Fax
010-62340519
Country
China
ProdList
1971
Advantage
55
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1998
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
More
Less

View Lastest Price from D-Luciferin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-luciferin 2591-17-5
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-15
Career Henan Chemical Co
Product
D-LUCIFERIN 2591-17-5
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-21

2591-17-5, D-LuciferinRelated Search:

D-Luciferin Coelenterazine LUCIFERIN, D-,LUCIFERIN,FIREFLY LUCIFERIN,FIREFLY LUCIFERIN,LUCIFERIN, D-,LUCIFERIN D-LUCIFERIN, ETHYL ESTER D-Luciferin potassium salt D-Luciferin sodium salt L-LUCIFERIN,L-Luciferin free acid, 99%,L-Luciferin free acid, 99%,L-LUCIFERIN LUCIFERASE 6-Benzothiazolol(7CI,8CI,9CI) D-luciferin 6-O-phosphate sodium,D-LUCIFERIN 6'-O-PHOSPHATE TRISODIUM &,D-LUCIFERIN 6'-O-PHOSPHATE TRISODIUM &,D-luciferin 6-O-phosphate sodium LUCIFERIN 6'-METHYL ETHER SODIUM SALT,luciferin 6'-methyl ether sodium,LUCIFERIN 6'-METHYL ETHER SODIUM SALT,luciferin 6'-methyl ether sodium 6-AMINO-D-LUCIFERIN,6-AMINO LUCIFERIN,6-AMINO-D-LUCIFERIN,6-AMINO LUCIFERIN D-LUCIFERIN-6-O-BETA-D-GALACTOPYRANOSIDE LUCIFERIN (RENILLA),LUCIFERIN (RENILLA) Cypridinia, Vargula Luciferin dihydrobromide,Cypridinia, Vargula Luciferin dihydrobromide,VARGULA LUCIFERIN DIHYDROBROMIDE,VARGULA LUCIFERIN DIHYDROBROMIDE L-LUCIFERIN, POTASSIUM SALT,L-LUCIFERIN, POTASSIUM SALT LUCIFERIN (WATASENIA),LUCIFERIN (WATASENIA) DMNPE-CAGED LUCIFERIN,DMNPE-CAGED LUCIFERIN

  • 4,5-DIHYDRO-2-(6-HYDROXY-2-BENZOTHIAZOLYL)-4-THIAZOLECARBOXY
  • 4,5-DIHYDRO-2-[6-HYDROXY-2-BENZOTHIAZOLYL]-4-THIAZOLE-CARBOXYLIC ACID
  • 4,5-DIHYDRO-(6-HYDROXY-2-BENZOTHIAZOYL)-4-THIAZOLE CARBOXYLIC ACID
  • LUCIFERIN, D-
  • LUCIFERIN
  • D(-)-2-(6'-HYDROXY-BENZOTHIAZOLYL)-DELTA2-THIAZOLINE-4-CARBOXYLIC ACID
  • D(-)-LUCIFERIN
  • D-LUCIFERIN
  • D-LUCIFERIN FIREFLY
  • D-Luciferin≥ 99% (HPLC)
  • Photinus luciferin
  • D-Luciferin, free acid *CAS#: 2591-17-5*
  • (S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4 thiazolecarboxylic acid
  • (4S)-2-(6-Hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
  • Luciferin, D- - Firefly Luciferin
  • 2-(6-oxo-1,3-benzothiazol-2-ylidene)-4-thiazolidinecarboxylic acid
  • FIREFLY LUCIFERIN
  • BEETLE LUCIFERIN
  • AURORA KA-6717
  • (S)-2-[6-HYDROXY-2-BENZOTHIAZOLYL]-2-THIAZOLENE-4
  • (S)-2-(6-HYDROXY-2-BENZOTHIAZOLYL)-2-THIAZOLINE-4-CARBOXYLIC ACID
  • (S)-4,5-dihydro-2-(6-hydroxybenzothiazol-2-yl)thiazole-4-carboxylic acid
  • D-Luciferin free acid, 99%
  • D-LUCIFERIN SYNTHETIC
  • D-LUCIFERIN SIGMAULTRA
  • D -LUCIFERIN SYNTHETIC CRYSTALLINE
  • Beetle luciferin Firefly luciferin
  • D-LUCIFERIN,FREEACID,ULTRAPURE
  • D-Leciferin
  • (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
  • D-(-)-Luciferin&nbsp
  • (D)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, Firefly (synthetic), 99%
  • D-LUCIFERINFREEACID,99%
  • D-Luciferin, Free acid >99.5%
  • 2-(6-Hydroxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid D-Luciferin
  • Firefly Luciferin, (S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid, 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid
  • (4S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4β-carboxylic acid
  • (4S)-2-(6-Hydroxybenzothiazole-2-yl)-2-thiazoline-4-carboxylic acid
  • D-(-)-Luciferin [Chemiluminescence Reagent]
  • (4S)-4,5-Dihydro-(6-hydroxy-2-benzothiazoyl)-4-thiazolecarboxylic acid
  • (S)-2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
  • D-(-)-Luciferin [Chemiluminescence Reagent]&gt
  • uciferin
  • 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)-
  • D-luciferin (Firefly luciferin)
  • D-Luciferin ex. Firefly, 99%
  • 7-Dihydroxyflavone
  • D-Luciferin Firefly, Free Acid
  • 2591-17-5
  • 2951-17-5
  • C11H7FN2O3S2
  • Biochemicals and Reagents
  • Analytical Enzymes
  • BioChemical
  • Enzymes, Inhibitors, and Substrates
  • Detection
  • Fluorescent Probes, Labels, Particles and Stains
  • Luciferase