Vascular endothelial growth factor-related protein
Description Source Background- Product Name
- Vascular endothelial growth factor-related protein
- Chemical Name
- Vascular endothelial growth factor-related protein
- Synonyms
- VRP;VEGFC;VEGF-C;Flt4-L;TBC1D8;LMPH1D;Flt4 ligand;VEGF-C human;VEGF-C from rat;VEGF-C from mouse
- CBNumber
- CB82895237
- Formula Weight
- 0
- MOL File
- Mol file
Vascular endothelial growth factor-related protein Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- white
- biological source
- rabbit
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SRP4633
- Product name
- VEGF-C human
- Purity
- recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
- Packaging
- 10μg
- Price
- $356
- Updated
- 2025/07/31
- Product number
- SRP3184
- Product name
- VEGF-C human
- Purity
- recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
- Packaging
- 20μg
- Price
- $356
- Updated
- 2025/07/31
- Product number
- SAB1303607
- Product name
- ANTI-VEGFC (VEGF3) (CENTER M263) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μL
- Price
- $496
- Updated
- 2025/07/31
- Product number
- SAB1303101
- Product name
- ANTI-VEGFC antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μl
- Price
- $496
- Updated
- 2025/07/31
- Product number
- SRP6020
- Product name
- VEGF-C from rat
- Purity
- recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
- Packaging
- 10μg
- Price
- $342
- Updated
- 2024/03/01
Vascular endothelial growth factor-related protein Chemical Properties,Usage,Production
Uses
VEGF-C human has been used to determine cell proliferation and survival.
Biological Activity
VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.
Description
VEGF-C Human Recombinant- contains 121 amino acids residues including 6 amino acid His-tag fused at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.
Source
Sf9, Insect Cells
Background
VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. Human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A.
Vascular endothelial growth factor-related protein Preparation Products And Raw materials
Raw materials
Preparation Products
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