trace amine receptor 1

Product Name: trace amine receptor 1
CAS No.: 1043495-96-0
Chemical Name: trace amine receptor 1
Synonyms: tar1;TRAR1;TAAR1;rTAR1;snorf33;RO-5256390;RP11-295F4.9;RO-5256390,RO5256390;trace amine receptor 1;trace amine associated receptor 1
CBNumber: CB82907965
Molecular Formula: C13H18N2O
Formula Weight: 218.29
MOL File: 1043495-96-0.mol

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trace amine receptor 1 Property

Boiling point:: 330.9±25.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
form: Solid
pka: 8.58±0.70(Predicted)
color: White to off-white
biological source: rabbit
optical activity: [α]/D 14 to 19°, c =1 in methanol

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1893
Product name: RO5256390
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1893
Product name: RO5256390
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $489
Updated: 2025/07/31

Sigma-Aldrich

Product number: HPA055614
Product name: Anti-TAAR1 antibody produced in rabbit
Purity: Prestige Antibodies<SUP>®</SUP> Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 100 μL
Price: $598
Updated: 2025/07/31

TRC

Product number: R637375
Product name: RO5256390
Packaging: 5mg
Price: $195
Updated: 2021/12/16

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trace amine receptor 1 Chemical Properties,Usage,Production

Uses

RO 5256390 is a trace amine-associated receptor 1(TAAR1) agonist which may be used as treatment of cocaine addiction.

Biological Activity

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaineμs reinforcng effects, and blocks binge-eating disorder.

in vivo

RO5256390 (0-15 μg Intracranial administration for 10 minutes; 0-10 mg/kg Intraperitoneal injection for 30 minutes; Single dose) can block compulsive overeating behavior in rats^[2].
RO5256390 (0.03-30 mg/kg; Oral administration; 15-60 minutes) exhibits pro-cognitive and antidepressant-like properties in rodent and primate models. RO5256390 produces a brain activation pattern reminiscent of Olanzapine (HY-14541) in rodents^[3].

Animal Model:	Wistar rats aged 45 days old with binge-like eating^[2]
Dosage:	0, 1.5, 5 and 15 μg per side; 0, 1, 3, 10 mg/kg
Administration:	Intracranial administration (ICV); 10 min prior to the operant sessions; Intraperitoneal injection (i.p.); 30 min prior to the operant sessions
Result:	Blocked binge-like eating in rats responding 1 h per day for a highly palatable sugary diet. Selectively reduced the rate and regularity of palatable food responding, but it did not affect either baseline intake or food restriction-induced overeating of the standard chow diet. Fully blocked compulsive-like eating when the palatable diet was offered in an aversive compartment of a light/dark conflict box, and blocked the conditioned rewarding properties of palatable food, as well as palatable food-seeking behavior in a second-order schedule of reinforcement.

Animal Model:	C57BL/6J mice, NMRI mice, Sprague-Dawley rats, Long-Evans rats and Cynomolgus macaques^[3]
Dosage:	0.03-3 mg/kg; 0.01-1 mg/kg; 1-30 mg/kg; 1-10 mg/kg; 0.3-3 mg/kg
Administration:	Oral administration (p.o.); 15min, 30 min or 60 min
Result:	Blocked psychostimulant-induced hyperactivity. Did not induce cataplexy or weight gain. Improved cognitive performance in cynomolgus macaques. Inhibited psychostimulant induced hyperactivity. Reversed cognitive deficits in rats.

trace amine receptor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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trace amine receptor 1 Suppliers

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1043495-96-0, trace amine receptor 1Related Search:

Anti-TAAR1/TA1 antibody produced in rabbit

rTAR1

snorf33

tar1

trace amine associated receptor 1

trace amine receptor 1

Anti-TAAR1 antibody produced in rabbit

RP11-295F4.9

RO-5256390

TAAR1

TRAR1

(4S)-4-((2S)-2-phenylbutyl)-4,5-dihydro-1,3-oxazol-2-ylamine

RO-5256390,RO5256390

2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-

(4S)-4-[(2S)-2-phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine

1043495-96-0