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trace amine receptor 1

Product Name
trace amine receptor 1
CAS No.
1043495-96-0
Chemical Name
trace amine receptor 1
Synonyms
tar1;TRAR1;TAAR1;rTAR1;snorf33;RO-5256390;RP11-295F4.9;RO-5256390,RO5256390;trace amine receptor 1;trace amine associated receptor 1
CBNumber
CB82907965
Molecular Formula
C13H18N2O
Formula Weight
218.29
MOL File
1043495-96-0.mol
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trace amine receptor 1 Property

Boiling point:
330.9±25.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
form 
Solid
pka
8.58±0.70(Predicted)
color 
White to off-white
biological source
rabbit
optical activity
[α]/D 14 to 19°, c =1 in methanol
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1893
Product name
RO5256390
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$121
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1893
Product name
RO5256390
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$489
Updated
2025/07/31
Sigma-Aldrich
Product number
HPA055614
Product name
Anti-TAAR1 antibody produced in rabbit
Purity
Prestige Antibodies<SUP>&#174;</SUP> Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging
100 μL
Price
$598
Updated
2025/07/31
TRC
Product number
R637375
Product name
RO5256390
Packaging
5mg
Price
$195
Updated
2021/12/16
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trace amine receptor 1 Chemical Properties,Usage,Production

Uses

RO 5256390 is a trace amine-associated receptor 1(TAAR1) agonist which may be used as treatment of cocaine addiction.

Biological Activity

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaineμs reinforcng effects, and blocks binge-eating disorder.

in vivo

RO5256390 (0-15 μg Intracranial administration for 10 minutes; 0-10 mg/kg Intraperitoneal injection for 30 minutes; Single dose) can block compulsive overeating behavior in rats[2].
RO5256390 (0.03-30 mg/kg; Oral administration; 15-60 minutes) exhibits pro-cognitive and antidepressant-like properties in rodent and primate models. RO5256390 produces a brain activation pattern reminiscent of Olanzapine (HY-14541) in rodents[3].

Animal Model:Wistar rats aged 45 days old with binge-like eating[2]
Dosage:0, 1.5, 5 and 15 μg per side;
0, 1, 3, 10 mg/kg
Administration:Intracranial administration (ICV); 10 min prior to the operant sessions;
Intraperitoneal injection (i.p.); 30 min prior to the operant sessions
Result:Blocked binge-like eating in rats responding 1 h per day for a highly palatable sugary diet.
Selectively reduced the rate and regularity of palatable food responding, but it did not affect either baseline intake or food restriction-induced overeating of the standard chow diet.
Fully blocked compulsive-like eating when the palatable diet was offered in an aversive compartment of a light/dark conflict box, and blocked the conditioned rewarding properties of palatable food, as well as palatable food-seeking behavior in a second-order schedule of reinforcement.
Animal Model:C57BL/6J mice, NMRI mice, Sprague-Dawley rats, Long-Evans rats and Cynomolgus macaques[3]
Dosage:0.03-3 mg/kg; 0.01-1 mg/kg; 1-30 mg/kg; 1-10 mg/kg; 0.3-3 mg/kg
Administration:Oral administration (p.o.); 15min, 30 min or 60 min
Result:Blocked psychostimulant-induced hyperactivity.
Did not induce cataplexy or weight gain.
Improved cognitive performance in cynomolgus macaques.
Inhibited psychostimulant induced hyperactivity.
Reversed cognitive deficits in rats.

trace amine receptor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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trace amine receptor 1 Suppliers

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1043495-96-0, trace amine receptor 1Related Search:


  • Anti-TAAR1/TA1 antibody produced in rabbit
  • rTAR1
  • snorf33
  • tar1
  • trace amine associated receptor 1
  • trace amine receptor 1
  • Anti-TAAR1 antibody produced in rabbit
  • RP11-295F4.9
  • RO-5256390
  • TAAR1
  • TRAR1
  • (4S)-4-((2S)-2-phenylbutyl)-4,5-dihydro-1,3-oxazol-2-ylamine
  • RO-5256390,RO5256390
  • 2-Oxazolamine, 4,5-dihydro-4-[(2S)-2-phenylbutyl]-, (4S)-
  • (4S)-4-[(2S)-2-phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine
  • 1043495-96-0