(R)-2-Flurbiprofen

Product Name: (R)-2-Flurbiprofen
CAS No.: 51543-40-9
Chemical Name: (R)-2-Flurbiprofen
Synonyms: Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
CBNumber: CB8302496
Molecular Formula: C15H13FO2
Formula Weight: 244.26
MOL File: 51543-40-9.mol

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(R)-2-Flurbiprofen Property

Melting point:: 110-113 °C(lit.)
Boiling point:: 376.2±30.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml
form: Crystalline Powder
pka: 4.14±0.10(Predicted)
color: White to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
HS Code: 29163900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70255
Product name: (R)-Flurbiprofen
Purity: ≥99%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 70255
Product name: (R)-Flurbiprofen
Purity: ≥99%
Packaging: 1g
Price: $133
Updated: 2024/03/01

Cayman Chemical

Product number: 70255
Product name: (R)-Flurbiprofen
Purity: ≥99%
Packaging: 250mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 70255
Product name: (R)-Flurbiprofen
Purity: ≥99%
Packaging: 500mg
Price: $116
Updated: 2024/03/01

TRC

Product number: F598730
Product name: (R)-Flurbiprofen
Packaging: 250mg
Price: $140
Updated: 2021/12/16

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(R)-2-Flurbiprofen Chemical Properties,Usage,Production

Description

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75^NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.

Uses

(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Definition

ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.

Biochem/physiol Actions

gamma secretase inhibitor; amyloid Abeta 42 lowering agent

(R)-2-Flurbiprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-2-Flurbiprofen Suppliers

Canada 1 China 155 Germany 1 India 7 Poland 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 8 United States 20 Global 197

Chengdu Senior Pharma Technology Co.Ltd.

Tel: +86-0838-2319818 +86-15982001943
Email: seniorpharma@163.com
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J & K SCIENTIFIC LTD.

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Email: jkinfo@jkchemical.com
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Fax: 86-21-61259102
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Energy Chemical

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BioBioPha Co., Ltd.

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Thermo Fisher Scientific

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AdooQ BioScience, LLC

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View Lastest Price from (R)-2-Flurbiprofen manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: (R)-2-Flurbiprofen 51543-40-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Mojin Biotechnology Co., Ltd

Product: (R)-2-Flurbiprofen 51543-40-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-11

Qiuxian Baitai New Material Co., LTD

Product: (R)-2-Flurbiprofen 51543-40-9
Price: US $90.00/KG
Min. Order: 10KG
Purity: 99.9%
Supply Ability: 100tons
Release date: 2021-10-29

51543-40-9, (R)-2-FlurbiprofenRelated Search:

Kresoxim-methyl Methylparaben Ethyl 2-(Chlorosulfonyl)acetate Biphenyl (Trifluoromethyl)trimethylsilane 2-Fluorophenylacetic acid 2-Phenylisobutyric acid Phenylmethylsulfonyl fluoride α-Lipoic Acid 4-Biphenylacetic acid Flurbiprofen 2-Methylbenzotrifluoride Bensulfuron methyl Methyl acrylate Trifluoromethanesulfonic anhydride 3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde Methyl

(R)-2-Fluoro-α-methyl-1,1'-biphenyl-4-acetic acid

(R)-α-Methyl-2-fluoro-1,1'-biphenyl-4-acetic acid

(R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid (Flurbiprofe

[1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-Methyl-,(aR)-

Flurizan

MPC 7869

(R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 97%

(R)-Flurbiprofen, >=99%

(R)-2-Flurbiprofenr

(R)-2-FLUBIPROFEN

(R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID

(R)-(-)-FLURBIPROFEN

(R)-FLURBIPROFEN

E-7869

(R)-2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid

Flurbiprofene

(R)-(-)-2-Fluoro-α-methyl-4-biphenylacetic acid

(R)-2-Flurbiprofen

Furbiprofen

[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (R)-

[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αR)-　

l-Flurbiprofen

(R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (FLURBIPROFEN)

E7869,Tarenflurbil,MPC7869

(R)-2-Flurbiprofen, Tarenflurbil

2-Flurbiprofen

Tarenflurbil

(R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propionic acid

(R)-Flurbiprofen (E7869

Flurbiprofen CRS

(R)-FL

Flurbiprofen (R)-Isomer

(R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid

(R)-2-Flurbiprofen USP/EP/BP

(2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic aci

R- Flurbiprofen-d4

(R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid

(-)-Flurbiprofen

(R)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid

51543-40-9

1543-40-9

Organic Building Blocks

Chiral Building Blocks

Asymmetric Synthesis

Carboxylic Acids

API

Pharmaceutical ingredients