7-Bromoquinolin-3-ol

Product Name: 7-Bromoquinolin-3-ol
CAS No.: 1261487-70-0
Chemical Name: 7-Bromoquinolin-3-ol
Synonyms: 7-Bromo-3-quinolinol;7-Bromoquinolin-3-ol;3-Quinolinol, 7-bromo-
CBNumber: CB83037690
Molecular Formula: C9H6BrNO
Formula Weight: 224.05
MOL File: 1261487-70-0.mol

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7-Bromoquinolin-3-ol Property

storage temp.: Sealed in dry,Room Temperature

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot

Product number: CD11310698
Product name: 7-Bromoquinolin-3-ol
Purity: 95+%
Packaging: 250mg
Price: $359
Updated: 2021/12/16

Alichem

Product number: 1261487700
Product name: 7-Bromo-3-hydroxyquinoline
Packaging: 250mg
Price: $488.01
Updated: 2021/12/16

Chemenu

Product number: CM145548
Product name: 7-Bromoquinolin-3-ol
Purity: 95%
Packaging: 1g
Price: $840
Updated: 2021/12/16

Crysdot

Product number: CD11310698
Product name: 7-Bromoquinolin-3-ol
Purity: 95+%
Packaging: 1g
Price: $898
Updated: 2021/12/16

Alichem

Product number: 1261487700
Product name: 7-Bromo-3-hydroxyquinoline
Packaging: 1g
Price: $1308.8
Updated: 2021/12/16

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7-Bromoquinolin-3-ol Chemical Properties,Usage,Production

Synthesis

1246548-95-7

1261487-70-0

General procedure for the synthesis of 7-bromoquinolin-3-ol from 7-bromo-3-methoxyquinoline: 7-bromo-3-methoxyquinoline (1.1 g, 4.62 mmol) was dissolved in acetic acid (20 mL), 48% hydrobromic acid (5.0 mL, 92 mmol) was added, and the reaction was carried out by refluxing the mixture at 120 °C for 4 days. The progress of the reaction was monitored by LCMS, showing a conversion of about 50%. Upon completion of the reaction, the mixture was poured into ice water and the pH was adjusted to alkaline with ammonia. Subsequently, the aqueous phase was extracted with ether (3 x 20 mL), and the organic phases were combined and concentrated. The residue was purified by fast column chromatography (eluent: 10-50% ethyl acetate/hexane) to afford the target product 7-bromoquinolin-3-ol (500 mg, 2.232 mmol, 48% yield) as a tan solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6), chemical shift δ (ppm): 7.55 (d, J=2.53 Hz, 1H), 7.63 (dd, J=8.59,2.02 Hz, 1H), 7.80 (d, J=8.84 Hz, 1H), 8.10 (d, J=1.77 Hz, 1H), 8.60 (d , J=2.78Hz, 1H), 10.51 (s, 1H).

References

[1] Patent: WO2013/52716, 2013, A1. Location in patent: Page/Page column 52
[2] Patent: WO2014/8223, 2014, A2. Location in patent: Page/Page column 74

7-Bromoquinolin-3-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Bromoquinolin-3-ol Suppliers

China 22 Global 22

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7-Bromoquinolin-3-ol

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1261487-70-0