7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Product Name
- 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- CAS No.
- 1032650-41-1
- Chemical Name
- 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Synonyms
- 7-BroMo-4-chloro-5H-pyrro...;7-broMo-4-chloro-5H-pyrrolo[3;7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine;5H-Pyrrolo[3,2-d]pyriMidine,7-broMo-4-chloro-;7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB51856180
- Molecular Formula
- C6H3BrClN3
- Formula Weight
- 232.47
- MOL File
- 1032650-41-1.mol
7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine Property
- Boiling point:
- 384.3±37.0 °C(Predicted)
- Density
- 1.996±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.91±0.40(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B701058
- Product name
- 7-Bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3H32-D-28
- Product name
- 7-Bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
- Product number
- 059848
- Product name
- 7-Bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Purity
- >98%
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- Y6629
- Product name
- 7-Bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 3H32-D-28
- Product name
- 7-Bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 5G
- Price
- $275
- Updated
- 2021/12/16
7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
93587-23-6
1032650-41-1
Under argon protection, 7-bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (100 mg, 0.5 mmol) was mixed with 6 mL of phosphorus oxytrichloride (POCl3) and the reaction was heated for 3 hours at 115 °C. After the reaction was completed, the mixture was cooled to room temperature and slowly poured into 300 mL of ice water with thorough stirring. The pH was adjusted to alkaline with potassium carbonate solution and subsequently extracted with ethyl acetate (EtOAc). The organic phases were combined, dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to afford 101 mg (93% yield) of the target product, 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine, as a beige solid, which could be used in the subsequent reaction without further purification.
References
[1] Patent: WO2008/70507, 2008, A2. Location in patent: Page/Page column 153
[2] Patent: WO2015/128334, 2015, A1. Location in patent: Page/Page column 90
[3] Patent: WO2011/113798, 2011, A2. Location in patent: Page/Page column 59-60
[4] Patent: US2013/102587, 2013, A1. Location in patent: Paragraph 0273; 0274
7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine manufacturers
- Product
- 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine 1032650-41-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
- Product
- 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine 1032650-41-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02