ChemicalBook > CAS DataBase List > H-VAL-NH2 HCL

H-VAL-NH2 HCL

Product Name
H-VAL-NH2 HCL
CAS No.
3014-80-0
Chemical Name
H-VAL-NH2 HCL
Synonyms
L-Val-NH2;Val-Nh2.Hcl;H-Val-NH HCl;L-Val-NH2·HCl;VALINE-NH2 HC;H-VAL-NH2 HCL;VALINE-NH2 HCL;H-L-VAL-NH2 HCL;L-Valinamide HCl;L-VALINE AMIDE HCL
CBNumber
CB8306409
Molecular Formula
C5H12N2O.ClH
Formula Weight
152.62
MOL File
3014-80-0.mol
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H-VAL-NH2 HCL Property

Melting point:
266-270 °C(lit.)
refractive index 
27 ° (C=1, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in methanol (50 mg/ ml-clear, colorless solution).
form 
Solid
color 
White to Almost white
optical activity
[α]25/D +25.8°, c = 1 in H2O
InChI
InChI=1/C5H12N2O.ClH/c1-3(2)4(6)5(7)8;/h3-4H,6H2,1-2H3,(H2,7,8);1H/t4-;/s3
InChIKey
XFCNYSGKNAWXFL-NDILARRWNA-N
SMILES
[C@@H](N)(C(=O)N)C(C)C.Cl |&1:0,r|
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
459232
Product name
L-Valinamide hydrochloride
Purity
97%
Packaging
5g
Price
$54.82
Updated
2025/07/31
TCI Chemical
Product number
V0102
Product name
L-Valinamide Hydrochloride
Purity
>98.0%(N)(T)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
V0102
Product name
L-Valinamide Hydrochloride
Purity
>98.0%(N)(T)
Packaging
25g
Price
$84
Updated
2025/07/31
TRC
Product number
V094210
Product name
L-ValineAmide
Packaging
10g
Price
$120
Updated
2021/12/16
AK Scientific
Product number
J94720
Product name
L-Valinamide Hydrochloride
Packaging
500g
Price
$380
Updated
2021/12/16
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H-VAL-NH2 HCL Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Valine Amide is a reagent used in the synthesis of alkylpyrazines. Also used in the synthesis of elastase inhibitory activity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

72-18-4

7732-18-5

75-24-1

3014-80-0

Preparation of Example 9 (S)-2-Amino-3-methylbutyramide hydrochloride: anhydrous ammonia was passed into 150 mL of cooled dichloromethane (ice bath) at 0°C until the solution was saturated. The mixture was cooled to 5°C and trimethylaluminum (136.2 mL of a 2M hexane solution, 272.4 mmol) was added slowly and dropwise under nitrogen protection. The resulting turbid solution was warmed to room temperature and stirred for 22 hours. L-valine (10.6 g, 90.79 mmol) was added in batches and stirring was continued at room temperature for 18 hours. The reaction mixture was cooled to 0 °C (ice-water bath) and 190 mL of 6N hydrochloric acid was added slowly and dropwise until the pH reached 2. The mixture was warmed to room temperature and stirred for 2 h. Subsequently, the pH was adjusted to 11-12 with 10% aqueous sodium hydroxide. 100 mL of dichloromethane and 100 mL of water were added to the alkaline solution, the organic layer was separated, dried over magnesium sulfate and concentrated to dryness under reduced pressure. The residue was dissolved in 100 mL of dichloromethane and acidified by passing hydrogen chloride gas. The solid formed was collected by filtration and dried under reduced pressure to give 6.8 g (49% yield) of L-valine amide hydrochloride with melting point 258°-260°C. IR (Nujol, cm-1 ) showed C=O (1686) and N-H (3387,3241) absorption peaks.1H NMR and 13C NMR (CDCl3 ) data were consistent with the target product. Elemental analysis (C5H13ClN2O) Calculated values: C, 39.35; H, 8.59; N, 18.35; Cl, 23.23; Measured values: C, 39.82; H, 8.52; N, 18.40; Cl, 23.13. Mass spectra (MS): m/e 117 (M+-Cl).

References

[1] Patent: US5643855, 1997, A

H-VAL-NH2 HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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H-VAL-NH2 HCL Suppliers

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View Lastest Price from H-VAL-NH2 HCL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
H-VAL-NH2 HCL 3014-80-0
Price
US $25.00/kg
Min. Order
100kg
Purity
99.5%
Supply Ability
100 mt
Release date
2024-11-26
Career Henan Chemical Co
Product
H-VAL-NH2 HCL 3014-80-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2018-12-24
Career Henan Chemical Co
Product
H-VAL-NH2 HCL 3014-80-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-27

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