Diamylamine Property

Melting point:

-44°C

Boiling point:

202-203 °C(lit.)

Density 

0.767 g/mL at 25 °C

vapor density 

5.42 (vs air)

vapor pressure 

0.3 mm Hg ( 20 °C)

refractive index 

n20/D 1.4258(lit.)

Flash point:

157 °F

pka

11.25±0.19(Predicted)

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

0.775 (25/4℃)

Water Solubility 

Slightly soluble (0.1-1 g/100 mL)

BRN 

906746

Dielectric constant

2.5

Stability:

Stable, but air-sensitive. Flammable. Incompatible with oxidizing agents.

CAS DataBase Reference

2050-92-2(CAS DataBase Reference)

NIST Chemistry Reference

1-Pentanamine, N-pentyl-(2050-92-2)

EPA Substance Registry System

Diamylamine (2050-92-2)

Safety

Hazard Codes 

T,N,C

Risk Statements 

23/24/25-34-37/38-24-22-50/53

Safety Statements 

26-27-36/37/39-45-61-60

RIDADR 

UN 2841 3/PG 3

WGK Germany 

3

RTECS 

RZ9100000

HS Code 

2921.19.6190

HazardClass 

3.2

PackingGroup 

III

Hazardous Substances Data

2050-92-2(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H400Very toxic to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

Diamylamine Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Chemical Properties

Diamylamine is a relatively strong base and forms salts with acids. Its vapors can form explosive mixtures with air.

Uses

Di-n-amylamine is manufactured from amyl chloride and ammonia. It is used in organic syntheses and as a solvent, rubber accelerator, flotation reagent, and corrosion inhibitor.

Uses

Dipentylamine was used in the synthesis of new melt-spinnable polymeric precursor to boron nitride ceramic fibers. It was used to compose background electrolyte for the separation of linear alkylbenzene sulfonates by nonaqueous capillary electrophoresis. It was employed as organic additive in the synthesis of pure AlP0₄-H₂ (aluminophosphate material).

Production Methods

Diamylamine is manufactured by the same processes as n-amylamine by reaction of amyl chloride with ammonia and then separated from the amylenes and amyl alcohol by steam distillation (Hawley 1977). It also can be synthesized by amination of alkyl halides at high temperature and pressure (Schweizer et al 1978). The commercial product may be a mixture of amyl isomers (HSDB 1989).

General Description

A clear colorless liquid with an ammonia-like odor. Very slightly soluble in water. Density 6.40 lb / gal (less than water) Vapors heavier than air. Flash point 152°F. Difficult to ignite. Moderately toxic. Contact with liquid may cause a chemical burn. Vapors may irritate respiratory tract. Used in the manufacture of rubber, resins, and dyes.

Air & Water Reactions

Flammable. Sensitive to air and heat. Slightly soluble in water.

Reactivity Profile

Diamylamine neutralizes acids to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Health Hazard

Diamylamine is a strong eye, skin, and respiratory irritant owing to its basicity (HSDB 1989). Vapor exposure results in irritation of the nose and throat with distressed breathing and coughing. Prolonged exposure may lead to pulmonary edema. Direct skin contact can cause secondary burns.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Industrial uses

Diamylamine is less widely used than n-amylamine with only 20 tons being manufactured in the U.S. in 1976. Its most widespread use is as a corrosion inhibitor and rubber accelerator (Hawley 1977). It is also useful as a solvent for oils, resins, and some cellulose esters. Introduction of the amyl group imparts oil solubility to otherwise oil-insoluble substances. Diamylamine also is used in flotation reagents, dyestuffs and as a cockroach repellent (HSDB 1989).

Safety Profile

Poison by inhalation, ingestion, and skin contact. A severe skin irritant. See also AMINES. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

Metabolism

In contrast to n-amylamine, little information is available on diamylamine metabolism, particularly with respect to its suitability as a substrate for the amine oxidases. Generally, the rate of oxidation of secondary amines by monoamine oxidase is slower than that of primary amines (Beard and Noe 1981). In agreement, Yamada et al (1965) demonstrated that crystalline amine oxidase prepared from Aspergillus niger oxidized diamylamine very slowly with respect to n-amylamine.
As with other secondary aliphatic amines, the propensity of diamylamine to form nitrosamines is of interest. It has been shown that treatment of diamylamine with nitrous acid in dilute aqueous solution gave optimum nitrosamine formation between pH 1 and 3, corresponding to stomach conditions (Sander et al 1968). When rats were fed a diet supplemented with sodium nitrite and secondary amines of low basicity, synthesis of nitrosamines in the stomach was observed. Malignant tumors arising through formation of nitrosamines in the stomach was demonstrated only when nitrite was present in the stomach concomitantly with secondary amines which readily formed carcinogenic nitrosamines.