3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

ChemicalBook > CAS DataBase List > 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

Product Name: 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
CAS No.: 67416-61-9
Chemical Name: 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
Synonyms: AKBA;Acetyl-11-keto-b-boswellic acid;Acetyl-11-keto-β-boswellic acid;3-acetyl-11-keto-β-Boswellic Acid;ACETYL-11-KETO-BETA-BOSWELLIC ACID;3-O-acetyl-11-keto-β-boswellic acid;3-O-Acetyl-11-keto-β-boswellic acid;AK-BETABA;AKBA, >98%;AKBA, 10 mM in DMSO
CBNumber: CB8309086
Molecular Formula: C32H48O5
Formula Weight: 512.73
MOL File: 67416-61-9.mol

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3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Property

Melting point:: 271℃
Boiling point:: 600.3±55.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: 4.28±0.70(Predicted)
color: White to Off-White
biological source: Boswellia serrata
LogP: 7.418 (est)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2918300000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9855
Product name: 3-Acetyl-11-keto-β-boswellic acid
Packaging: 5mg
Price: $417
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1076261
Product name: 3-Acetyl-11-keto-β-boswellic acid
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $741
Updated: 2024/03/01

Sigma-Aldrich

Product number: 74607
Product name: 3-O-Acetyl-11-keto-β-boswellic acid
Purity: analytical standard
Packaging: 5MG
Price: $429
Updated: 2022/05/15

Cayman Chemical

Product number: 11672
Product name: 3-acetyl-11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 11672
Product name: 3-acetyl-11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

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3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production

Description

3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC₅₀ = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.

Uses

3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent.

Definition

ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.

in vitro

akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1].

in vivo

pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].

IC 50

1.5 μm

References

[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180.

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Suppliers

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View Lastest Price from 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID manufacturers

BINBO BIOLOGICAL CO.,LTD

Product: Acetyl-11-Keto-β -Boswellic Acid 67416-61-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2024-04-15

Shanghai Standard Technology Co., Ltd.

Product: Acetyl-11-keto-β-boswellic acid 67416-61-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-26

Career Henan Chemical Co

Product: Urs-12-en-23-oic acid,3-(acetyloxy)-11-oxo-, (3a,4b)- 67416-61-9
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

67416-61-9, 3-ACETYL-11-KETO-BETA-BOSWELLIC ACIDRelated Search:

11-KETO-BETA-BOSWELLIC ACID (R)-N-Acetyl-2-naphthylalanine ethylene bis[3,3-bis(3-tert-butyl-4-hydroxyphenyl)butyrate] Corosolic acid Ursolic acid Ursodeoxycholic acid AC-P-BROMO-DL-PHE-OH β-Elemonic Acid (3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid Ginsenoside CK ISOBAVACHALCONE yemuoside YM(10) ALPHA-BOSWELLIC ACID 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID BETA-BOSWELLIC ACID Erucic Acid BRASSIDIC ACID 3-ACETYL-BETA-BOSWELLIC ACID

BOSWELLIC ACID, ACETYL KETO

3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

3-ACETYL-11-KETONE-BETA-ACETYLBOSWELLIC ACID

AKBA

AK-BETABA

ACETYL-11-KETO-B-BOSWELLIC ACID, 3

ACETYL-11-KETO-BETA-BOSWELLIC ACID

3-O-acetyl-11-keto-β-boswellic acid

3-O-ACETYL-11-KETO-BOSWELLIC ACID, BOSWELLIA SERRATA, >99%

11-keto-β-boswellic acid acetate

3-ACETYL-11-KETO-B-BOSWELLIC ACID

3-Acetyl-11-keto-(-boswellicacid

3-O-Acetyl-11-keto--boswellicacid,Boswelliaserrata

3-Acetyl-11-Keto-Beta-Boswellic Acid (20 mg)

Urs-12-en-23-oic acid, 3-(acetyloxy)-11-oxo-, (3a,4b)-

Acetyl-11-keto-b-boswellic acid

3α-Acetoxy-11-oxo-12-ursen-24-oic acid

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata

Beta-boswellic acid,3-acetyl,11-keto、AKBA

3-Acetyl-11-keto-β-boswellic acid, 98%, from Boswellia carterii Birdw

3-O-Acetyl-11-keto-β-boswellic acid from Boswellia serrata

AKBA, >98%

Boswellic Acid Impurity 3

Acetyl-11-keto--boswellic acid (AKBA)

Urs-12-en-23-oic acid, 3-(acetyloxy)-11-oxo-, (3α,4β)-

3-acetyl-11-keto-β-Boswellic Acid

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID USP/EP/BP

acetyl-11-keto-β-boswellic acidd acid

AKBA (Acetyl-11-keto-β-boswellic acid)

Acetyl-11-keto-β-boswellic acid

3-O-Acetyl-11-keto-β-boswellic acid

(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-Acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid

Acetyl-11-keto-b-boswellicaci

3-Acetyl-11-keto-beta-boswellic acid(AKBA)

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata

AKBA, 10 mM in DMSO

67416-61-9

C32H48O5

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