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Sacubitril Impurity 7

Product Name
Sacubitril Impurity 7
CAS No.
149709-44-4
Chemical Name
Sacubitril Impurity 7
Synonyms
LBQ657;LCZ696-4;Sacubitrilat;Deethyl Sakuba;LCZ-696 Impurity 1;SACUBITRIL DI ACID;Diacid of Sacubitril;LCZ696 impurities124;LBQ-657(Sacubitrilat);Sacubitrilat (LBQ-657)
CBNumber
CB83133439
Molecular Formula
C22H25NO5
Formula Weight
383.44
MOL File
149709-44-4.mol
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Sacubitril Impurity 7 Property

Boiling point:
705.4±60.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)
form 
A crystalline solid
pka
4.59±0.23(Predicted)
color 
White to off-white
optical activity
[α]/D -35 to -27°, c =1 in methanol
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19829
Product name
LBQ657
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
19829
Product name
LBQ657
Purity
≥98%
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
19829
Product name
LBQ657
Purity
≥98%
Packaging
10mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
19829
Product name
LBQ657
Purity
≥98%
Packaging
25mg
Price
$894
Updated
2021/12/16
TRC
Product number
D288245
Product name
DesethylSacubitril
Packaging
10mg
Price
$580
Updated
2021/12/16
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Sacubitril Impurity 7 Chemical Properties,Usage,Production

Uses

Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biological Activity

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysinμs degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Sacubitril Impurity 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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149709-44-4, Sacubitril Impurity 7Related Search:

Sacubitril Impurity 72 Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate (2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Sacubitril Impurity 3 Sacubitril Impurity 19 Sacubitril Impurity 23 ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride Sacubitril Impurity 21 Sacubitril Impurity 6 Sacubitril Impurity 7 Sacubitril Impurity 5 Sacubitril Impurity 20 Sacubitril Impurity 24 HCl Sildenafil EP Impurity G Sacubitril Impurity 8

  • (2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid
  • LCZ696-4
  • Diacid of Sacubitril
  • LBQ657
  • Sacubitrilat
  • LCZ-696 Impurity 1
  • Sacubitrilat (LBQ-657)
  • Sacubitril Desethyl Impurity
  • LCZ696 Impurity 900-04
  • Deethyl Sakuba
  • Sacubitril metabolite LBQ 657
  • [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, (αR,γS)-
  • 4-[[(1S,3R)-1-[([1,1'-Biphenyl]-4-yl)methyl]-3-methyl-4-hydroxy-4-oxobutyl]amino]-4-oxobutanoic acid
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)- 2-methylpentanoic aci
  • Diacid of Sacubitril/ Sacubitril Desethyl Impurity/ Sacubitrilat
  • LCZ696 impurities124
  • Sacubitril metabolite LBQ 657Q: What is Sacubitril metabolite LBQ 657 Q: What is the CAS Number of Sacubitril metabolite LBQ 657 Q: What is the storage condition of Sacubitril metabolite LBQ 657 Q: What are the applications of Sacubitril metabolite LBQ 657
  • quinoline,6-bromo-7-chloro-
  • SACUBITRIL DI ACID
  • Salcubatra calcium impurity J
  • LBQ-657(Sacubitrilat)
  • (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid
  • Sacubitril metabolite LBQ 657-[d4]
  • Sacubitril Impurity 4 (LBQ-657) (desethyl) (Sacubitrilat)
  • Valsartan Impurity D-1
  • Sacubitril Diacid Impurity
  • LCZ696 impurity 900-04（LBQ657）
  • Sacubitrilat, 10 mM in DMSO
  • Sacubitril Diacid impurity: (2R,4S)-4-(3-carboxypropanamido)-2-methyl-5-(4-phenylphenyl)pentanoic acid
  • 149709-44-4
  • 14709-44-4