Ensartinib (X-396)

Product Name: Ensartinib (X-396)
CAS No.: 1370651-20-9
Chemical Name: Ensartinib (X-396)
Synonyms: 561.44;C26H27Cl2FN6O3;Ensartinib (X-396);X396; X-396; X 396; ENSARTINIB;;6-Amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((3R,5S)-3,5-dimethylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide;6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-{4-[(3R,5S)-3,5-dimethylpiperazine-1-carbonyl]phenyl}pyridazine-3-carboxamide;3-Pyridazinecarboxamide, 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]carbonyl]phenyl]-
CBNumber: CB83151688
Molecular Formula: C26H27Cl2FN6O3
Formula Weight: 561.44
MOL File: 1370651-20-9.mol

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Ensartinib (X-396) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white
InChIKey: GLYMPHUVMRFTFV-QLFBSQMISA-N
SMILES: C1(C(NC2=CC=C(C(N3C[C@H](C)N[C@H](C)C3)=O)C=C2)=O)=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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Ensartinib (X-396) Chemical Properties,Usage,Production

Uses

Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.

in vivo

The effects of Ensartinib (X-396) in vivo against H3122 xenografts are examined. A pharmacokinetic study reveals that Ensartinib shows substantial bioavailability and moderate half-lives in vivo. Nude mice harboring H3122 xenografts are treated with Ensartinib at 25mg/kg bid. Ensartinib significantly delays the growth of tumors compared to vehicle alone. In the xenograft experiments, Ensartinib appears well-tolerated in vivo. Mouse weight is unaffected by Ensartinib treatment. Drug-treated mice appear healthy and do not display any signs of compound related toxicity. To further assess potential side effects of Ensartinib, additional systemic toxicity and toxico-kinetic studies are performed in Sprague Dawley (SD) rats. Following 10 days of repeated oral administration of Ensartinib at 20, 40, 80 mg/kg in SD rats, all animals survive to study termination. The no significant toxicity (NST) levels are determined to be 80mg/kg for Ensartinib. At NST levels, Ensartinib achieves an AUC of 66 μM×hr and a C_max of 7.19 μM^[1].

References

[1] Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71(14):4920-31. DOI:10.1158/0008-5472.CAN-10-3879

Ensartinib (X-396) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ensartinib (X-396) manufacturers

Moxin Chemicals

Product: Ensartinib 1370651-20-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000000
Release date: 2025-02-22

1370651-20-9, Ensartinib (X-396)Related Search:

5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid) 1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)- 3-Pyridineacetamide, N-cyclohexyl-α-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-, (αR)- 9H-Thioxanthen-9-one, 2,7-bis(2-aminoethoxy)-

561.44

C26H27Cl2FN6O3

Ensartinib (X-396)

X396; X-396; X 396; ENSARTINIB;

3-Pyridazinecarboxamide, 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]carbonyl]phenyl]-

6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-{4-[(3R,5S)-3,5-dimethylpiperazine-1-carbonyl]phenyl}pyridazine-3-carboxamide

6-Amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((3R,5S)-3,5-dimethylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide

1370651-20-9

APIS