Azadibenzocyclooctyne-PEG4-acid

Product Name: Azadibenzocyclooctyne-PEG4-acid
CAS No.: 1870899-46-9
Chemical Name: Azadibenzocyclooctyne-PEG4-acid
Synonyms: ADIBO-PEG(5)-acid;DBCO-NHCO-PEG4-acid;DBCO-NHCO-PEG5-acid;DBCO-PEG4-CH2CH2COOH;DBCO-NH-PEG4-CH2CH2COOH;DBCO-PEG5-acid,DBCO-PEG5-COOH;Azadibenzocyclooctyne-PEG4-acid;Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid;4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-
CBNumber: CB83155020
Molecular Formula: C32H40N2O9
Formula Weight: 596.67
MOL File: 1870899-46-9.mol

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Azadibenzocyclooctyne-PEG4-acid Property

Boiling point:: 855.9±65.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DMF, DCM
pka: 4.28±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22449
Product name: DBCO-NHCO-PEG5-acid
Purity: 95%
Packaging: 25mg
Price: $175
Updated: 2021/12/16

BroadPharm

Product number: BP-22449
Product name: DBCO-NHCO-PEG5-acid
Purity: 95%
Packaging: 500mg
Price: $1195
Updated: 2021/12/16

purepeg

Product number: 488304
Product name: DBCO-NH-PEG4-CH2CH2COOH
Purity: min.95%
Packaging: 100mg
Price: $380
Updated: 2021/12/16

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Azadibenzocyclooctyne-PEG4-acid Chemical Properties,Usage,Production

Description

DBCO-NHCO-PEG5-acid is an analog of DBCO-Acid with a hydrophilic PEG spacer arm, which improves water solubility. This reagent is a non-activated building block with enhanced solubility in aqueous media and can thus be used to derivatize amine-containing molecule through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-NHCO-PEG4-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Cleavable Linker; PEGs

References

[1] Vukic Soskic, et al. Method for binding biologically active molecules to surfaces. DE102014215208A1.

Azadibenzocyclooctyne-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Azadibenzocyclooctyne-PEG4-acid Suppliers

China 34 United States 6 Global 40

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
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Jinan elephant international trading co., LTD

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Beijing Jin Ming Biotechnology Co., Ltd.

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Chemleader Biomedical Co., Limited.

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Shanghai 9i Technology Co., Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Hangzhou Huarong Pharm Co., Ltd.

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Career Henan Chemica Co

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Chengdu Excellent Technology Co., Ltd.

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1870899-46-9, Azadibenzocyclooctyne-PEG4-acidRelated Search:

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Azadibenzocyclooctyne-PEG4-acid

DBCO-NH-PEG4-CH2CH2COOH

DBCO-PEG4-CH2CH2COOH

DBCO-NHCO-PEG5-acid

DBCO-PEG5-acid,DBCO-PEG5-COOH

DBCO-NHCO-PEG4-acid

4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-

ADIBO-PEG(5)-acid

Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid

1870899-46-9

C32H40N2O9